4-硝基喹啉1-氧化物（4NQO）诱导的舌癌和7,12-二甲基苯（a）蒽（DMBA）诱导的颊囊癌是最常见和经典的化学致癌物诱导的口腔癌动物模型。本研究的目的是提供4NQO和DMBA诱导的实验性口腔癌的研究趋势和特点。4NQO和DMBA诱导的实验性口腔癌的论文自1962年以来发表。所有符合条件的论文均于12月12日检索。 2023 年 5 月，来自 Scopus 数据库。关于 4NQO 和 DMBA 诱导的实验性口腔癌发生的论文分别有 506 篇和 349 篇，被引用次数分别为 10,152 次和 6306 次。 4NQO上的论文中识别出了大鼠、舌肿瘤、饮用水、肿瘤微环境、环氧合酶（COX）-2等常见的鲜明关键词；并在DMBA论文中找出了仓鼠、颊囊、脂质过氧化、谷胱甘肽、抗氧化剂、局部用药等常见关键词。重要的是，从 4NQO 和 DMBA 的论文中分别鉴定出了 105 种和 65 种潜在的化学预防药物。此外，在两种动物模型中同时研究了COX-2抑制剂、姜黄素、大蒜等15种有前景的药物。本研究首次报告了4NQO和DMBA诱导的实验性口腔癌发生的科学计量特征。重要的是，我们确定了口腔癌化学预防药物的宝贵资料，这将有助于研究人员和调查人员研究口腔癌化学预防。© 2023 中华民国牙科科学协会。 Elsevier B.V. 的出版服务

4-Nitroquinoline 1-oxide (4NQO)-induced tongue carcinoma and 7,12-dimethlybenz(a)anthracene (DMBA)-induced cheek pouch carcinoma are the most common and classical chemical carcinogen-induced animal models of oral carcinogenesis. The purpose of this study was to provide the research trends and characteristics of 4NQO- and DMBA-induced experimental oral carcinogenesis.The papers on both 4NQO- and DMBA-induced experimental oral carcinogenesis were published since 1962. All the eligible papers were retrieved on 12 May 2023 from the Scopus database.There were 506 and 349 papers on 4NQO- and DMBA-induced experimental oral carcinogenesis with 10,152 and 6306 citations, respectively. The common distinctive keywords such as rat, tongue neoplasms, drinking water, tumor microenvironment, and cyclooxygenase (COX)-2 were identified in the papers on 4NQO; and the common keywords such as hamster, cheek pouch, lipid peroxidation, glutathione, antioxidants, and topical drug administration were identified in the papers on DMBA. Importantly, 105 and 65 potential chemopreventive agents were identified from the papers on 4NQO and DMBA, respectively. Furthermore, 15 promising agents such as COX-2 inhibitor, curcumin, garlic were researched concurrently in both the two animal models.This study for the first time reports the scientometric characteristics of 4NQO- and DMBA-induced experimental oral carcinogenesis. Importantly, we identify a valuable profile for oral cancer chemopreventive agents, which will aid researchers and investigators in studying oral cancer chemoprevention.© 2023 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.