癌症患者临终关怀期间临床辅助水化存在争议；临床环境和国家之间的做法各不相同，并且缺乏证据。为了检查呼吸困难、呼吸道分泌物或精神错乱是否与临终时接受肠外补水相关，并根据性别、年龄和死亡地点进行调整。瑞典登记处姑息治疗数据库用于收集有关生命最后一天肠外水化使用情况以及上周三种症状发生情况的数据。 2011 年至 2021 年期间在医院、疗养院和专门姑息治疗机构中死于癌症的成年人均被纳入其中。使用 χ2 检验和逻辑回归检查肠外水合与症状之间的相关性。该研究总共纳入了 147,488 名患者。肠外补水更常用于年轻人、男性和急症医院（与其他环境相比），所有三项比较中 p < 0.001。患有血液恶性肿瘤 (20%) 和卵巢癌 (16%) 的患者最有可能接受肠外补液，而脑肿瘤患者 (6%) 的可能性最小。上周所有三种分析症状（呼吸困难、呼吸道分泌物和精神错乱）的出现与生命最后一天接受肠外补水显着相关（p < 0.001）。在根据年龄、性别和死亡地点进行调整的最终逻辑回归模型中，与肠外水合仍然相关的唯一症状是呼吸困难（OR 1.56，95% CI 1.50-1.6）。肠外水合与呼吸困难增加之间存在关联癌症患者。肠外补液在男性、年轻患者以及患有血液系统恶性肿瘤或卵巢癌的患者中更为普遍，并且在急性医院环境中最为普遍。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Clinically assisted hydration during end-of-life care among patients with cancer is controversial; practice varies between clinical settings and countries, and there is a lack of evidence.To examine whether breathlessness, respiratory secretion, or confusion correlates with receiving parenteral hydration during end of life, adjusted for sex, age, and place of death.The Swedish Register of Palliative Care database was used to collect data about the usage of parenteral hydration during the last day of life, and the occurrence of three symptoms during the last week. Adults dying from cancer during 2011-2021 in hospitals, in residential care homes, and within specialized palliative care were included. Correlation between parenteral hydration and symptoms was examined using χ2-test and logistic regression.A total of 147,488 patients were included in the study. Parenteral hydration was more often prescribed to younger persons, to men, and in acute hospitals (compared to other settings), p < 0.001 in all three comparisons. Patients with hematological malignancies (20%) and ovarian cancer (16%) were most likely to receive parenteral hydration, while those with brain tumors (6%) were least likely. The presence of all three analyzed symptoms during the last week (breathlessness, respiratory secretion, and confusion) were significantly correlated with having received parenteral hydration during the last day of life (p < 0.001). In the final logistic regression model adjusted for age, sex, and place of death, the only symptom with remaining correlation to parenteral hydration was breathlessness (OR 1.56, 95% CI 1.50-1.6).There is an association between parenteral hydration and increased breathlessness in patients with cancer. Provision of parenteral hydration is more prevalent in men, younger patients, and those with hematological malignancies or ovarian cancer, and most widespread in acute hospital settings.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.