牙周炎是一种破坏牙周组织的炎症性疾病。另一方面，白介素 20 (IL-20) 被认为是一种与各种慢性炎症性疾病相关的有效血管生成、趋化和促炎细胞因子。 IL-20在破骨细胞生成和成骨细胞生成的调节中具有重要作用。本研究旨在评估IL-20对牙周破坏的影响。本研究共纳入60名参与者，其中30名全身和牙周健康（对照组），30名全身健康但患有牙周炎（牙周炎）团体）。从参与者身上采集龈沟液（GCF）和血清样本进行生化分析。采用酶联免疫吸附法测定IL-20、肿瘤坏死因子(TNF)-α、IL1β/IL-10、RANKL/骨保护素(OPG)和基质金属蛋白酶-8(MMP8)的水平。统计分析采用独立 t 检验、Pearson 相关系数和卡方检验。GCF IL-20、RANKL、RANKL/OPG、血清 IL-20、RANKL、RANKL/OPG、MMP-8、TNF牙周炎组的-α、IL-1B和IL-1β/IL-10值显着高于对照组。对照组的 GCF OPG 和血清 IL-10 值显着高于牙周炎组。各组之间血清 OPG 值没有观察到统计学上的显着差异。血清IL-20值与血清RANKL、RANKL/OPG、MMP-8、TNF-α、IL-1β值及牙周临床参数呈显着正相关。 ROC曲线显示：GCF IL-20的AUC = 0.788，血清IL-20的AUC = 1.000。研究结果发现IL-20与牙周炎相关。 IL-20在牙周发病机制中的作用与破骨细胞生成和胶原蛋白降解有关。可以想象，IL-20 可能通过影响 RANKL/OPG 比率和促炎细胞因子来增加骨质破坏。© 2024 John Wiley

Periodontitis is an inflammatory disease that destroys periodontal tissues. Interleukin-20 (IL-20), on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. This study aimed to evaluate the effect of IL-20 on periodontal destruction.In this study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group), and 30 were systemically healthy but had periodontitis (periodontitis group). Gingival crevicular fluid (GCF) and serum samples were collected from the participants for biochemical analysis. Enzyme-linked immunosorbent assay was used to determine the levels of IL-20, tumor necrosis factor (TNF)-α, IL1β/IL-10, RANKL/osteoprotegerin (OPG), and matrix metalloproteinase-8 (MMP8). For statistical analysis, the independent t-test, Pearson correlation coefficients, and the Chi-square test were used.GCF IL-20, RANKL, RANKL/OPG, serum IL-20, RANKL, RANKL/OPG, MMP-8, TNF-α, IL-1B, and IL-1β/IL-10 values were found to be statistically significantly higher in the periodontitis group than in the control group. GCF OPG and serum IL-10 values were found to be statistically significantly higher in the control group than in the periodontitis group. No statistically significant difference was observed between the groups in serum OPG values. A statistically significantly positive correlation was observed between serum IL-20 value and serum RANKL, RANKL/OPG, MMP-8, TNF-α, IL-1β values, and periodontal clinical parameters. The ROC curves showed: AUC = 0.788 for GCF IL-20, and AUC = 1.000 for serum IL-20.According to the results of the study, IL-20 was found to be associated with periodontitis. The role of IL-20 in periodontal pathogenesis is related to osteoclastogenesis and collagen degradation. It is conceivable that IL-20 may increase bone destruction by both affecting the RANKL/OPG ratio and proinflammatory cytokines.© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.