癌症中的表观基因组编辑：潜在治疗方案的进展和挑战。
Epigenome editing in cancer: Advances and challenges for potential therapeutic options.
发表日期：2024
作者：
Seung-Won Lee, Connor Mitchell Frankston, Jungsun Kim
来源：
International Review of Cell and Molecular Biology
摘要：
癌症是由遗传和非遗传环境因素引起的疾病。表观遗传改变（部分归因于非遗传因素）可能导致癌症的发生。表观遗传变化可能发生在肿瘤抑制基因或癌基因中，或者它们可能导致整体细胞状态变化，使细胞异常。基因编辑技术的最新进展显示出癌症治疗的潜力。在此，我们将讨论我们目前对癌症中发生的表观遗传改变的了解，以及可应用于开发治疗方案的表观遗传编辑技术。版权所有 © 2024。由 Elsevier Inc. 出版。
Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic alterations, some attributed to non-genetic factors, can lead to cancer development. Epigenetic changes can occur in tumor suppressors or oncogenes, or they may contribute to global cell state changes, making cells abnormal. Recent advances in gene editing technology show potential for cancer treatment. Herein, we will discuss our current knowledge of epigenetic alterations occurring in cancer and epigenetic editing technologies that can be applied to developing therapeutic options.Copyright © 2024. Published by Elsevier Inc.