姑息治疗 (PC) 的目标是改善患有致命疾病的患者及其家人的生活质量 (QoL)。理想情况下，PC 在危及生命的疾病的早期就得到整合。低收入环境中家庭护理人员 (FC) 早期 PC 的需求较少受到关注。这项观察性横断面研究的目的是探讨埃及新诊断的不可治愈癌症患者家庭护理人员 (FC) 所经历的负担，并描述其关系95 名新诊断为无法治愈癌症的成年患者的成年 FC 完成了 22 项 Zarit Burden 访谈 (ZBI-22)、患者健康问卷 (PHQ-9) 和简表 12 (SF-12)分别评估功能型家庭的照护负担、抑郁症和生活质量。 ZBI-22 评分中位数 (IQR) 为 17(11-24)，34% 的功能型家庭有显着负担（ZBI-22 评分 > 20）。对晚期日常生活活动丧失的帮助以及较长时间护理时间的可用性与较高的护理负担显着相关（分别为 P = 0.004 和 0.047）。负担较重的 FC 的 PHQ-9 分数显着较高 (P = 0.0003)。 ZBI-22 评分与 SF-12 的身体疼痛、一般健康、心理健康、身体机能、角色情绪和社会功能分量表/项目之间存在显着负相关。很大一部分埃及 FC 的不可治愈癌症患者经历过这种情况病程早期的重大负担。这种负担与抑郁症状和较差的生活质量、身体、心理和社交方面有关。在低收入环境中，需要对无法治愈的癌症患者进行早期 PC 干预。版权所有 © 2024 美国临终关怀和姑息医学学会。由爱思唯尔公司出版。保留所有权利。

The goal of palliative care (PC) is to improve the quality of life (QoL) of patients with life-limiting illnesses as well as their families. Ideally, PC is integrated early in the course of life-limiting illnesses. Less attention has been paid to the need for early PC for family caregivers (FCs) in lower-income settings.This observational cross-sectional study was conducted to explore the burden experienced by FCs of newly diagnosed incurable cancer patients in Egypt and characterize its relation to depression and QoL.Ninety-five adult FCs of adult patients with newly diagnosed incurable cancer completed the 22-item Zarit Burden Interview (ZBI-22), Patient Health Questionnaire (PHQ-9), and Short Form 12 (SF-12) to assess caregiving burden, depression, and QoL among FCs, respectively.The median (IQR) ZBI-22 score was 17(11-24) and 34% of FCs had significant burden (ZBI-22 score > 20). Assistance with late loss activities of daily living and availability for longer caregiving duration were associated significantly with higher caregiving burdens (P = 0.004 and 0.047, respectively). FCs with significant burden had significantly higher PHQ-9 scores (P = 0.0003). There was a significant negative correlation between ZBI-22 scores and the bodily pain, general health, mental health, physical function, role emotional, and social function subscales/items of SF-12.A substantial proportion of Egyptian FCs of incurable cancer patients experience significant burden early in the course of the disease. This burden is associated with depressive symptoms and worse QoL dimensions, physical, psychological, and social. In a lower-income setting, early PC interventions for FCs of incurable cancer patients are needed.Copyright © 2024 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.