癌症干细胞（CSC）的存在极大地限制了放射疗法（RT）的治疗效果。有效消除潜在的CSC对于提高RT的有效性至关重要。在本研究中，我们开发了一种仿生混合纳米系统（PMC），该系统由MnCO3作为内核和血小板膜（PM）作为外壳组成。通过利用膜表面蛋白的特异性识别特性，PMC 能够精确靶向 CSC。使用碳酸锰纳米颗粒（MnCO3 NP）进行声动力疗法（SDT），该纳米颗粒在超声（US）照射下产生丰富的活性氧（ROS），从而损害CSC的自我更新能力并根除CSC。随后的 RT 有效地消除了常见的肿瘤细胞。体外细胞实验和体内动物研究都表明，PMC 介导的 SDT 可以协同增强 RT，选择性地对抗 CSC，同时抑制肿瘤生长，且没有明显的副作用。我们的研究结果为增强疗效和提高疗效提供了新的见解。 RT 的安全概况。© 2024 Jiang et al.

The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy of radiotherapy (RT). Efficient elimination of potential CSCs is crucial for enhancing the effectiveness of RT.In this study, we developed a biomimetic hybrid nano-system (PMC) composed of MnCO3 as the inner core and platelet membrane (PM) as the outer shell. By exploiting the specific recognition properties of membrane surface proteins, PMC enables precise targeting of CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO3 NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity and eradicating CSCs. Subsequent RT effectively eliminates common tumor cells.Both in vitro cell experiments and in vivo animal studies demonstrate that SDT mediated by PMC synergistically enhances RT to selectively combat CSCs while inhibiting tumor growth without noticeable side effects.Our findings offer novel insights for enhancing the efficacy and safety profiles of RT.© 2024 Jiang et al.