乳腺癌是最常见的恶性肿瘤之一，严重威胁女性健康。能量代谢重编程是乳腺癌恶变的一大特征。与正常细胞相比，肿瘤细胞更有效地重新编程代谢过程，将营养供应转化为恶性增殖和进展所需的葡萄糖、氨基酸和脂质。非编码RNA（ncRNA）是一类功能性RNA分子，不翻译成蛋白质，但调节靶基因的表达。 NcRNA 已被证明参与能量代谢的各个方面，包括糖酵解、谷氨酰胺分解和脂肪酸合成。本综述重点关注乳腺癌中代谢调节 ncRNA 的代谢调节机制和临床应用。我们总结了代谢调节 ncRNA 在乳腺癌内分泌治疗、靶向治疗、化疗、免疫治疗和放疗耐药中所发挥的重要作用，以及它们作为治疗靶点和生物标志物的潜力。讨论了当前靶向代谢和非编码 RNA 治疗策略的困难和前景。© 2024。作者。

Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compared to normal cells, tumor cells reprogram metabolic processes more efficiently, converting nutrient supplies into glucose, amino acid and lipid required for malignant proliferation and progression. Non-coding RNAs(ncRNAs) are a class of functional RNA molecules that are not translated into proteins but regulate the expression of target genes. NcRNAs have been demonstrated to be involved in various aspects of energy metabolism, including glycolysis, glutaminolysis, and fatty acid synthesis. This review focuses on the metabolic regulatory mechanisms and clinical applications of metabolism-regulating ncRNAs involved in breast cancer. We summarize the vital roles played by metabolism-regulating ncRNAs for endocrine therapy, targeted therapy, chemotherapy, immunotherapy, and radiotherapy resistance in breast cancer, as well as their potential as therapeutic targets and biomarkers. Difficulties and perspectives of current targeted metabolism and non-coding RNA therapeutic strategies are discussed.© 2024. The Author(s).