紫檀芪 (PST) 是葡萄、蓝莓和其他水果中天然衍生的芪化合物。它也是一种天然膳食化合物，具有抗氧化、抗炎、抗肿瘤等广泛的生物活性。基于紫檀芪骨架的化学支架的结构修饰对于药物发现非常重要。在这项研究中，利用紫檀芪骨架设计了具有高活性和低毒性的新型抗炎化合物。共发现并合成了30个新化合物，并对其抗炎活性和安全性进行了筛选。其中，化合物E2比塞来昔布活性最高（针对NO：IC50 = 0.7μM）。进一步研究表明，化合物E2通过阻断LPS诱导的NF-κB/MAPK信号通路激活发挥抗炎活性。体内实验表明，化合物E2对小鼠急性结肠炎有良好的缓解作用。总之，化合物E2可能是一种有前途的抗炎先导化合物。

Pterostilbene (PST) is a naturally derived stilbene compound in grapes, blueberries, and other fruits. It is also a natural dietary compound with a wide range of biological activities such as antioxidant, anti-inflammatory, antitumor, and so on. Structural modifications based on the chemical scaffold of the pterostilbene skeleton are of great importance for drug discovery. In this study, pterostilbene skeletons were used to design novel anti-inflammatory compounds with high activity and low toxicity. A total of 30 new were found and synthesised, and their anti-inflammatory activity and safety were screened. Among them, compound E2 was the most active (against NO: IC50 = 0.7 μM) than celecoxib. Further studies showed that compound E2 exerted anti-inflammatory activity by blocking LPS-induced NF-κB/MAPK signalling pathway activation. In vivo experiments revealed that compound E2 had a good alleviating effect on acute colitis in mice. In conclusion, compound E2 may be a promising anti-inflammatory lead compound.