色氨酸分解代谢在癌细胞的代谢重新连接中发挥重要作用，以支持肿瘤发生和进展的特殊需求。色氨酸途径的分解代谢产物犬尿氨酸具有抑制肿瘤细胞免疫反应的能力。在本研究中，我们进行了内部和外部队列研究，以揭示色氨酸 2,3-双加氧酶 (TDO) 对肺腺癌 (LUAD) 的重要性。我们的研究进一步证明TDO2表达与LUAD细胞的增殖、存活和侵袭相关，靶向TDO2治疗LUAD肿瘤可能是一种潜在的治疗策略。

Tryptophan catabolism plays an important role in the metabolic reconnection in cancer cells to support special demands of tumor initiation and progression. The catabolic product of the tryptophan pathway, kynurenine, has the capability of suppressing the immune reactions of tumor cells. In this study, we conducted internal and external cohort studies to reveal the importance of tryptophan 2,3-dioxygenase (TDO) for lung adenocarcinoma (LUAD). Our study further demonstrated that the TDO2 expression was associated with the proliferation, survival, and invasion of LUAD cells, and targeting TDO2 for LUAD tumors could be a potential therapeutic strategy.