脂肪瘤，包括脂肪瘤、非典型脂肪瘤（ALT）、粘液样脂肪肉瘤（ML）和去分化脂肪肉瘤（DL），通常使用磁共振成像（MRI）来诊断。通过 MRI 鉴别脂肪瘤和 ALT 常常具有挑战性。 18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）最近已用于软组织肿瘤的肿瘤分期和复发的诊断和评估。最大标准化摄取值（SUVmax）与多种癌症的恶性程度呈正相关。本研究旨在评估 18F-FDG PET/CT 在脂肪瘤鉴别诊断中的 SUVmax。该研究纳入了 2013 年 1 月至 2021 年 9 月期间接受 18F-FDG PET/CT 诊断脂肪瘤的患者。对经病理诊断或手术标本证实的脂肪瘤患者进行脂肪瘤SUVmax评估。本研究包括44例脂肪瘤患者（n=19）、ALT（n=12）、ML（n=9）和DL（ n=4）。脂肪瘤、ALT、ML 和 DL 的平均 SUVmax 分别为 0.99±1.41、1.92±0.95、5.21±4.94 和 9.29±1.43。脂肪瘤的 SUVmax 显着低于 ALT、ML 和 DL（p<0.05）。 ALT 的 SUVmax 显着低于 ML 和 DL (p<0.05)。 ML 和 DL 之间没有观察到显着差异。脂肪瘤或 ALT 的 SUVmax 显着低于脂肪瘤性肉瘤。脂肪瘤的 SUVmax 显着低于 ALT，有助于术前分化。 18F-FDG-PET/CT 可作为脂肪瘤肿瘤鉴别诊断的有效工具。版权所有 2024，国际抗癌研究所。

Lipomatous tumors, including lipomas, atypical lipomatous tumors (ALTs), myxoid liposarcomas (MLs), and dedifferentiated liposarcomas (DLs), are often diagnosed using magnetic resonance imaging (MRI). Differential diagnosis of lipomas and ALTs by MRI is often challenging. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has recently been used for the diagnosis and evaluation of tumor staging and recurrence of soft tissue tumors. The maximum standardized uptake value (SUVmax) is positively associated with malignant grade in several cancers. This study aimed to evaluate SUVmax of 18F-FDG PET/CT in the differential diagnosis of lipomatous tumors.Patients who underwent 18F-FDG PET/CT for the diagnosis of lipomatous tumors between January 2013 and September 2021 were included in the study. Patients with lipomatous tumors, confirmed by pathological diagnosis or surgical specimens, were evaluated for lipomatous tumor SUVmax.This study included 44 patients with lipomas (n=19), ALTs (n=12), MLs (n=9), and DLs (n=4). The mean SUVmax of lipomas, ALTs, MLs, and DLs was 0.99±1.41, 1.92±0.95, 5.21±4.94, and 9.29±1.43, respectively. Lipomas showed a significantly lower SUVmax than did ALTs, MLs, and DLs (p<0.05). ALTs demonstrated a significantly lower SUVmax than did MLs and DLs (p<0.05). No significant differences were observed between MLs and DLs.Lipomas or ALTs had a significantly lower SUVmax than lipomatous sarcomas. Lipomas had a significantly lower SUVmax than ALTs, aiding in their preoperative differentiation. 18F-FDG-PET/CT could serve as a potent tool for the differential diagnosis of lipomatous tumors.Copyright 2024, International Institute of Anticancer Research.