程序性细胞死亡蛋白 6 (PDCD6) 是一种进化上保守的 Ca2 结合蛋白。 PDCD6 参与调节不同细胞区室中的多方面和多效性细胞过程。例如，核 PDCD6 调节细胞凋亡和选择性剪接。 PDCD6 是细胞质中外壳蛋白复合物 II 依赖性内质网到高尔基体囊泡运输所必需的。最近的进展表明细胞质 PDCD6 参与细胞骨架动力学和先天免疫反应的调节。此外，膜 PDCD6 通过运输复合物依赖性膜出芽所需的内体分选复合物参与膜修复。有趣的是，细胞外囊泡富含PDCD6。而且PDCD6的异常表达与多种疾病尤其是癌症密切相关。因此，PDCD6 是体内多方面但关键的蛋白质。为了更全面地了解 PDCD6 功能并关注和促进 PDCD6 研究，本综述总结了其在不同亚细胞区室、过程和病理学中的作用的关键进展。© 2024 Wiley periodicals LLC。

Programmed cell death protein 6 (PDCD6) is an evolutionarily conserved Ca2+ -binding protein. PDCD6 is involved in regulating multifaceted and pleiotropic cellular processes in different cellular compartments. For instance, nuclear PDCD6 regulates apoptosis and alternative splicing. PDCD6 is required for coat protein complex II-dependent endoplasmic reticulum-to-Golgi apparatus vesicular transport in the cytoplasm. Recent advances suggest that cytoplasmic PDCD6 is involved in the regulation of cytoskeletal dynamics and innate immune responses. Additionally, membranous PDCD6 participates in membrane repair through endosomal sorting complex required for transport complex-dependent membrane budding. Interestingly, extracellular vesicles are rich in PDCD6. Moreover, abnormal expression of PDCD6 is closely associated with many diseases, especially cancer. PDCD6 is therefore a multifaceted but pivotal protein in vivo. To gain a more comprehensive understanding of PDCD6 functions and to focus and stimulate PDCD6 research, this review summarizes key developments in its role in different subcellular compartments, processes, and pathologies.© 2024 Wiley Periodicals LLC.