PC-A (1) 是一种溴代去甲肾上腺素，对三阴性乳腺癌 (TNBC) 细胞系表现出选择性抗增殖活性。这种独特的活性促使我们建立全合成，以促进构效关系（SAR）研究和选择性优化。以(R)-香芹酮为原料，通过Mukaiyama羟醛反应和十氢化萘结构进行侧链延伸，实现了1的对映选择性首次全合成。评估了合成的十氢萘衍生物和去溴 PC-A (2) 对五种人类肿瘤细胞系（包括 TNBC）的抗增殖活性，以评估初步的 SAR 相关性。

PC-A (1), a bromo nor-eremophilane, showed selective antiproliferative activity against a triple-negative breast cancer (TNBC) cell line. This unique activity prompted us to establish a total synthesis to facilitate a structure-activity relationship (SAR) study and selectivity optimization. An enantioselective first total synthesis of 1 was achieved starting from (R)-carvone through a side chain extension with a Mukaiyama aldol reaction and decalin construction. The synthesized decalin derivatives and debromo PC-A (2) were evaluated for antiproliferative activity against five human tumor cell lines, including TNBC, to assess preliminary SAR correlations.