从 Streptomyces cavourensis（一种与环节动物 Paraleonnates uschakovi 相关的肠道细菌）中鉴定出三种独特的线性寡聚缩酚酸肽，命名为 Cavomycins A-C (1-3)。这些缩酚肽的结构是通过光谱方法和化学衍生技术相结合确定的，包括甲醇分解、改进的Mosher方法、先进的Marfey方法和苯基甘氨酸甲酯衍生化。化合物1-3中独特的二肽基残基排列表明它们不是缬氨霉素的降解产物。化合物2及其甲基化衍生物2a对PANC-1胰腺癌细胞表现出抗增殖活性，IC50值分别为1.2和1.7 μM。

Three unique linear oligomeric depsipeptides, designated as cavomycins A-C (1-3), were identified from Streptomyces cavourensis, a gut bacterium associated with the annelid Paraleonnates uschakovi. The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Mosher's method, advanced Marfey's methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds 1-3 indicate that they are not degradation products of valinomycin. Compound 2 and its methylation derivative 2a exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC50 values of 1.2 and 1.7 μM, respectively.