治疗头颈癌 (HNC) 的同步放化疗可能会导致使人衰弱的毒性。瑜伽疗法等有针对性的运动可以缓解治疗相关的后遗症；因此，这项试点随机对照试验检验了瑜伽干预的可行性和初步效果。由于家庭护理人员报告护理效率较低且痛苦程度较高，因此我们将他们作为积极的研究参与者纳入本试验。HNC 患者及其护理人员被随机分配到 15 节双元瑜伽课程或候补对照 (WLC) 组。在随机分组之前，患者完成了标准症状（MDASI-HN），患者和护理人员完成了生活质量（SF-36）评估。该 15 个疗程的计划与患者的治疗计划同时进行。参与者在患者放化疗的最后一天以及 30 天后再次接受评估。在整个治疗过程中以及最多 30 天后，记录患者的急诊就诊、计划外入院和胃饲管放置情况。同意率为 76%，37 组患者被随机分组​​。瑜伽组的参与者平均完成了 12.5 节课程，并评价该项目“有益”。与 WLC 组患者相比，瑜伽组患者的症状干扰和 HNC 症状严重程度在临床上显着减少，生活质量也更好。他们入院 (OR=3.00)、急诊科就诊 (OR=2.14) 和/或饲管置入 (OR=1.78) 的可能性也较小。瑜伽疗法似乎是一种可行、可接受且可能的治疗方法。针对接受放化疗的 HNC 患者有效的行为支持护理策略。需要进行更大规模的疗效试验。版权所有 © 2024。由 Elsevier Inc. 出版。

Concurrent chemoradiation to treat head and neck cancer (HNC) may result in debilitating toxicities. Targeted exercise such as yoga therapy may buffer against treatment-related sequelae; thus, this pilot RCT examined the feasibility and preliminary efficacy of a yoga intervention. Because family caregivers report low caregiving efficacy and elevated levels of distress, we included them in this trial as active study participants.HNC patients and their caregivers were randomized to a 15-session dyadic yoga program or a waitlist control (WLC) group. Prior to randomization, patients completed standard symptom (MDASI-HN) and patients and caregivers completed quality of life (SF-36) assessments. The 15-session program was delivered parallel to patients' treatment schedules. Participants were re-assessed at patients' last day of chemoradiation and again 30 days later. Patients' emergency department visits, unplanned hospital admissions and gastric feeding tube placements were recorded over the treatment course and up to 30 days later.With a consent rate of 76%, 37 dyads were randomized. Participants in yoga group completed a mean of 12.5 sessions and rated the program as "beneficial." Patients in the yoga group had clinically significantly less symptom interference and HNC symptom severity and better QOL than those in the WLC group. They were also less likely to have a hospital admission (OR=3.00), emergency department visit (OR=2.14), and/or a feeding tube placement (OR=1.78).Yoga therapy appears to be a feasible, acceptable, and possibly efficacious behavioral supportive care strategy for HNC patients undergoing chemoradiation. A larger efficacy trial is warranted.Copyright © 2024. Published by Elsevier Inc.