听音乐（ML）已被证明对癌症患者有有益的影响。然而，需要新的干预方法。我们的目的是确定使用移动应用程序 (GloMus) 进行的基于 iso 原理的 ML 是否可以改善接受干细胞治疗的患者的症状负担、生活质量 (QoL)、焦虑和抑郁急性髓系白血病 (AML) 移植 (SCT) 和强化诱导化疗。在这项随机对照临床试验中，我们将 71 名患者分配到 ML 组或标准治疗 (SC) 组，并按入院原因分层（AML、同种异体 SCT） ，或住院/门诊自体 SCT）。入院后，机器学习小组的参与者被邀请参加每日机器学习课程，旨在将消极情绪转变为积极情绪（iso 原则）。干预措施包括聆听按每分钟节拍和音调排序的预先录制的古典音乐。在每次治疗之前和之后对 ML 组的症状负担（埃德蒙顿症状评估系统修订版）进行评估。 ML 和 SC 组每周测量焦虑、抑郁（医院焦虑和抑郁量表）和 QoL（癌症治疗功能评估 - 骨髓移植/白血病）。同种异体和住院自体 SCT ML 组的症状负担均减轻干预后。在所有实验组中，机器学习课程后都观察到了临床上重要的改善。在入院不同周时，两组（ML 与 SC）之间在焦虑、抑郁和 QoL 方面没有发现差异。ML 基于我们使用 GloMus 进行的创新 iso 原则策略，减轻了接受同种异体和住院患者自体 SCT。 （ClinicalTrials.gov 编号，NCT05696457）。版权所有 © 2024。由 Elsevier Inc. 出版。

Music listening (ML) has been shown to have a beneficial effect on patients with cancer. However, novel intervention approaches are needed.We aimed to determine whether ML based on the iso-principle, conducted using a mobile application (GloMus), improves symptom burden, quality of life (QoL), anxiety, and depression in patients undergoing stem cell transplantation (SCT) and intensive induction chemotherapy for acute myeloid leukemia (AML).In this randomized controlled clinical trial, we assigned 71 patients to the ML or standard care (SC) groups, stratified by the reason for admission (AML, allogeneic-SCT, or inpatient/outpatient autologous-SCT). Upon admission, participants in the ML groups were invited to undergo daily ML sessions designed to change negative moods into positive ones (iso-principle). The intervention consisted of listening to pre-recorded classical music ordered by beats per minute and tonality. Symptom burden (Edmonton Symptom Assessment System-Revised) was assessed in the ML groups before and after each session. Anxiety, depression (Hospital Anxiety and Depression Scale), and QoL (Functional Assessment of Cancer Therapy-Bone Marrow Transplantation/Leukemia) were measured weekly in the ML and SC groups.Symptom burden in both allogeneic- and inpatient autologous-SCT ML groups reduced after the intervention. In all experimental groups, clinically important improvements were observed after ML sessions. No differences were found between the groups (ML vs. SC) at different weeks of admission regarding anxiety, depression, and QoL.ML based on our innovative iso-principle strategy, conducted using GloMus, reduced the symptom burden in patients undergoing allogeneic- and inpatient autologous-SCT. (ClinicalTrials.gov number, NCT05696457).Copyright © 2024. Published by Elsevier Inc.