英国生物库的嗜酸性粒细胞与癌症风险之间的关联
Associations between eosinophils and cancer risk in the UK Biobank
影响因子:4.70000
分区:医学2区 / 肿瘤学2区
发表日期:2024 Aug 01
作者:
Jeanny H Wang, Charles S Rabkin, Eric A Engels, Minkyo Song
摘要
嗜酸性粒细胞在肿瘤微环境中表现出抗肿瘤的细胞毒性反应，并可能有助于肿瘤免疫监视。为了评估循环嗜酸性粒细胞与癌症风险之间的关系，我们分析了来自英国生物库的443,542名38-73岁成年人的数据，最初是没有癌症的，并进行了一年的随访，并进行了白细胞数量的测量。使用多变量COX回归，我们估计了58种癌症类型的绝对嗜酸性粒细胞计数（AEC）的危害比（AHR）和95％置信区间（95％CI），以调整相关的混杂因素。在5。8年的中位随访期间，诊断出22,747例事件癌症。我们观察到了AEC和整体癌症风险之间达到Bonferroni显着性的逆关联（AHR，95％CI 0.97，0.95-0.98）。值得注意的是，有16种癌症类型显示了与AEC的边界关联（P <.05），其中12种表现出逆关系。 These included four hematologic cancers (acute and other myeloid leukemia, other lymphocytic leukemia, and chronic lymphocytic leukemia/small lymphocytic lymphoma; aHR range; 0.58-0.87) and eight nonhematologic cancers (melanoma and nose/middle ear, soft tissue/heart, gum/other mouth, tongue, lung, colon, and breast癌症； AHR范围：0.65-0.95）。较高的AEC表现出与肝内胆管癌，霍奇金淋巴瘤，弥漫性大B细胞淋巴瘤和慢性髓样白血病（AHR范围：1.13-1.42）的风险增加的临界显着相关性。我们迄今为止最大的研究提供了有关血液嗜酸性粒细胞与事件癌症的全面清单之间关系的见解。 AEC与整体癌症风险之间的反向关联表明，嗜酸性粒细胞在肿瘤监测中起保护作用。于2024年出版。本文是美国政府的工作，并且在美国的公共领域中。
Abstract
Eosinophils exhibit anti-tumor cytotoxic responses in the tumor microenvironment and may contribute to tumor immunosurveillance. To assess the relationship between circulating eosinophils and cancer risk, we analyzed data from 443,542 adults aged 38-73 in the UK Biobank, who were initially cancer-free, had over a year of follow-up, and baseline white blood cell count measurements. Using multivariable Cox regression, we estimated hazard ratios (aHR) and 95% confidence intervals (95%CI) for each quartile increase in absolute eosinophil count (AEC) across 58 cancer types, adjusting for relevant confounders. During a median follow-up of 5.8 years, 22,747 incident cancer cases were diagnosed. We observed an inverse association, which met Bonferroni significance, between AEC and overall cancer risk (aHR, 95%CI 0.97, 0.95-0.98). Notably, 16 cancer types showed borderline associations (p <.05) with AEC, with 12 types displaying an inverse relationship. These included four hematologic cancers (acute and other myeloid leukemia, other lymphocytic leukemia, and chronic lymphocytic leukemia/small lymphocytic lymphoma; aHR range; 0.58-0.87) and eight nonhematologic cancers (melanoma and nose/middle ear, soft tissue/heart, gum/other mouth, tongue, lung, colon, and breast cancers; aHR range: 0.65-0.95). Higher AEC showed a borderline significant association with increased risk for intrahepatic bile duct cancer, Hodgkin lymphoma, diffuse large B-cell lymphoma, and chronic myeloid leukemia (aHR range: 1.13-1.42). Our study, the largest to date, provides insights into the relationship between blood eosinophils and a comprehensive list of incident cancers. The inverse association between AEC and overall cancer risk suggests a protective role for eosinophils in tumor surveillance.Published 2024. This article is a U.S. Government work and is in the public domain in the USA.