茶和咖啡消费与胆道癌风险的关联：胆道癌联合研究项目

Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project

HEPATOLOGY

影响因子:15.8

分区:医学1区 Top / 胃肠肝病学1区

发表日期:2024 Jun 01

作者: Yu-Han Huang, Erikka Loftfield, Ilona Argirion, Hans-Olov Adami, Demetrius Albanes, Andrew T Chan, Veronika Fedirko, Gary E Fraser, Neal D Freedman, Graham G Giles, Patricia Hartge, Verena Katzke, Synnove F Knutsen, James Lacey, Linda M Liao, Juhua Luo, Roger L Milne, Katie M O'Brien, Ulrike Peters, Jenny N Poynter, Mark P Purdue, Kim Robien, Sven Sandin, Dale P Sandler, Veronica W Setiawan, Jae H Kang, Tracey G Simon, Rashmi Sinha, Trang VoPham, Stephanie J Weinstein, Emily White, Xuehong Zhang, Bin Zhu, Katherine A McGlynn, Peter T Campbell, Mei-Hsuan Lee, Jill Koshiol

DOI: 10.1097/HEP.0000000000000748

摘要

茶和咖啡是全球广泛消费的饮料。我们评估它们与胆道癌（BTC）发病风险的关系。通过整合15项研究的数据，来自胆道癌联合研究项目（Biliary Tract Cancers Pooling Project），分析了茶和咖啡摄入与胆道癌发生的相关性。根据日摄入量，将参与者分为不喝者（0杯/天）、中等饮用者（>0且<3杯/天）及大量饮用者（≥3杯/天）。采用Cox模型估算多变量HR及95%置信区间（CI）。在2991万1千744人年随访中，诊断出胆囊癌851例，肝内胆管癌588例，肝外胆管癌753例，Vater乳头癌458例。喝茶者的胆囊癌发生率明显低于不喝者（HR=0.77；95% CI，0.64-0.91），肝内胆管癌亦呈逆相关（HR=0.81；95% CI，0.66-1.00）。然而，肝外胆管癌和Vater乳头癌未观察到显著关联。咖啡摄入则与胆囊癌呈正相关，喝咖啡越多，风险越高（<3杯/天 HR=1.29；95% CI，1.01-1.66；≥3杯/天 HR=1.49；95% CI，1.11-1.99；趋势值=0.01），但在只限咖啡饮用者中无明显相关性。与其他胆道癌的关联证据较少。结论：喝茶与胆囊癌及可能的肝内胆管癌风险降低有关，而咖啡摄入与胆囊癌风险升高有关，需进一步研究验证。

Abstract

Tea and coffee are widely consumed beverages worldwide. We evaluated their association with biliary tract cancer (BTC) incidence.We pooled data from 15 studies in the Biliary Tract Cancers Pooling Project to evaluate associations between tea and coffee consumption and biliary tract cancer development. We categorized participants as nondrinkers (0 cup/day), moderate drinkers (>0 and <3 cups/day), and heavy drinkers (≥3 cups/day). We estimated multivariable HRs and 95% CIs using Cox models. During 29,911,744 person-years of follow-up, 851 gallbladder, 588 intrahepatic bile duct, 753 extrahepatic bile duct, and 458 ampulla of Vater cancer cases were diagnosed. Individuals who drank tea showed a statistically significantly lower incidence rate of gallbladder cancer (GBC) relative to tea nondrinkers (HR=0.77; 95% CI, 0.64-0.91), and intrahepatic bile duct cancer (IHBDC) had an inverse association (HR=0.81; 95% CI, 0.66-1.00). However, no associations were observed for extrahepatic bile duct cancer (EHBDC) or ampulla of Vater cancer (AVC). In contrast, coffee consumption was positively associated with GBC, with a higher incidence rate for individuals consuming more coffee (HR<3 cups/day =1.29; 95% CI, 1.01-1.66; HR≥3 cups/day =1.49; 95% CI, 1.11-1.99, Ptrend=0.01) relative to coffee nondrinkers. However, there was no association between coffee consumption and GBC when restricted to coffee drinkers. There was little evidence of associations between coffee consumption and other biliary tract cancers.Tea consumption was associated with a lower incidence of GBC and possibly IHBDC. Further research is warranted to replicate the observed positive association between coffee and GBC.