茶和咖啡消费与胆道癌的风险：胆道癌的合并项目
Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project
影响因子:15.80000
分区:医学1区 Top / 胃肠肝病学1区
发表日期:2024 Jun 01
作者:
Yu-Han Huang, Erikka Loftfield, Ilona Argirion, Hans-Olov Adami, Demetrius Albanes, Andrew T Chan, Veronika Fedirko, Gary E Fraser, Neal D Freedman, Graham G Giles, Patricia Hartge, Verena Katzke, Synnove F Knutsen, James Lacey, Linda M Liao, Juhua Luo, Roger L Milne, Katie M O'Brien, Ulrike Peters, Jenny N Poynter, Mark P Purdue, Kim Robien, Sven Sandin, Dale P Sandler, Veronica W Setiawan, Jae H Kang, Tracey G Simon, Rashmi Sinha, Trang VoPham, Stephanie J Weinstein, Emily White, Xuehong Zhang, Bin Zhu, Katherine A McGlynn, Peter T Campbell, Mei-Hsuan Lee, Jill Koshiol
摘要
茶和咖啡在全球范围内广泛消费。我们评估了它们与胆道癌（BTC）发病率的关联。我们从胆道癌的15项研究中汇总了数据，以评估茶与咖啡消费与胆道癌的发展之间的关联。我们将参与者归类为非裁缝（0杯/天），中等饮酒者（> 0和<3杯/天）和饮酒者（≥3杯/天）。我们使用COX模型估计了多变量HR和95％CI。在29,911,744人的随访期间，诊断为诊断为29,911,744人的随访，851个胆囊，588个肝内胆管，753次肝外胆管和458个Ampulla的Vater癌病例。喝茶的个体在统计学上相对于非茶剂的胆囊癌（GBC）的发病率显着降低（HR = 0.77; 95％CI，0.64-0.91）和肝内胆管癌（IHBDC）的疾病（IHBDC）逆关联（HR = 0.81; 95％CI，0.66-1.66-1.66-1.66-1.66-1.666-1.00）。然而，未观察到肝外胆管癌（EHBDC）或Vater癌（AVC）的膜的关联。相比之下，咖啡的消费与GBC呈正相关，食用更多咖啡的人的发病率较高（HR <3杯/天= 1.29; 95％CI，1.01-1.66;HR≥3杯/天= 1.49; 95％CI，1.11-1.99，1.11-1.99，Ptrend = 0.01），ptrend = 0.01）与咖啡nondrimersersers。但是，咖啡消费与GBC之间没有关联。几乎没有证据表明咖啡消费与其他胆道癌之间的关联。TEA消费与GBC和可能的IHBDC发病率较低有关。有必要进行进一步的研究，以复制观察到的咖啡与GBC之间的正相关。
Abstract
Tea and coffee are widely consumed beverages worldwide. We evaluated their association with biliary tract cancer (BTC) incidence.We pooled data from 15 studies in the Biliary Tract Cancers Pooling Project to evaluate associations between tea and coffee consumption and biliary tract cancer development. We categorized participants as nondrinkers (0 cup/day), moderate drinkers (>0 and <3 cups/day), and heavy drinkers (≥3 cups/day). We estimated multivariable HRs and 95% CIs using Cox models. During 29,911,744 person-years of follow-up, 851 gallbladder, 588 intrahepatic bile duct, 753 extrahepatic bile duct, and 458 ampulla of Vater cancer cases were diagnosed. Individuals who drank tea showed a statistically significantly lower incidence rate of gallbladder cancer (GBC) relative to tea nondrinkers (HR=0.77; 95% CI, 0.64-0.91), and intrahepatic bile duct cancer (IHBDC) had an inverse association (HR=0.81; 95% CI, 0.66-1.00). However, no associations were observed for extrahepatic bile duct cancer (EHBDC) or ampulla of Vater cancer (AVC). In contrast, coffee consumption was positively associated with GBC, with a higher incidence rate for individuals consuming more coffee (HR<3 cups/day =1.29; 95% CI, 1.01-1.66; HR≥3 cups/day =1.49; 95% CI, 1.11-1.99, Ptrend=0.01) relative to coffee nondrinkers. However, there was no association between coffee consumption and GBC when restricted to coffee drinkers. There was little evidence of associations between coffee consumption and other biliary tract cancers.Tea consumption was associated with a lower incidence of GBC and possibly IHBDC. Further research is warranted to replicate the observed positive association between coffee and GBC.