茶和咖啡消费与胆道癌风险的关联：胆道癌汇集项目。
Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project.
发表日期：2024 Jun 01
作者：
Yu-Han Huang, Erikka Loftfield, Ilona Argirion, Hans-Olov Adami, Demetrius Albanes, Andrew T Chan, Veronika Fedirko, Gary E Fraser, Neal D Freedman, Graham G Giles, Patricia Hartge, Verena Katzke, Synnove F Knutsen, James Lacey, Linda M Liao, Juhua Luo, Roger L Milne, Katie M O'Brien, Ulrike Peters, Jenny N Poynter, Mark P Purdue, Kim Robien, Sven Sandin, Dale P Sandler, Veronica W Setiawan, Jae H Kang, Tracey G Simon, Rashmi Sinha, Trang VoPham, Stephanie J Weinstein, Emily White, Xuehong Zhang, Bin Zhu, Katherine A McGlynn, Peter T Campbell, Mei-Hsuan Lee, Jill Koshiol
来源：
HEPATOLOGY
摘要：
茶和咖啡是全世界广泛消费的饮料。我们评估了它们与胆道癌 (BTC) 发病率的关联。我们汇总了胆道癌汇集项目中 15 项研究的数据，以评估茶和咖啡的摄入量与胆道癌发生之间的关联。我们将参与者分为不饮酒者（0 杯/天）、中度饮酒者（>0 且<3 杯/天）和重度饮酒者（≥3 杯/天）。我们使用 Cox 模型估计了多变量 HR 和 95% CI。在29,911,744人年的随访中，诊断出胆囊癌851例、肝内胆管癌588例、肝外胆管癌753例、壶腹癌458例。与不喝茶的人相比，喝茶的人胆囊癌（GBC）的发病率在统计学上显着降低（HR=0.77；95% CI，0.64-0.91），并且肝内胆管癌（IHBDC）呈负相关（HR= 0.81；95% CI，0.66-1.00）。然而，没有观察到与肝外胆管癌（EHBDC）或 Vater 壶腹癌（AVC）之间的关联。相比之下，咖啡摄入量与 GBC 呈正相关，咖啡摄入量越多，GBC 的发病率越高（HR<3 杯/天 =1.29；95% CI，1.01-1.66；HR≥3 杯/天 =1.49；95% CI，1.11-1.99，Ptrend=0.01）相对于不喝咖啡的人。然而，当仅限于咖啡饮用者时，咖啡消费与 GBC 之间没有关联。几乎没有证据表明咖啡摄入量与其他胆道癌症之间存在关联。喝茶与 GBC 和可能的 IHBDC 发病率较低相关。需要进一步的研究来复制所观察到的咖啡与 GBC 之间的正相关关系。版权所有 © 2023 美国肝病研究协会。
Tea and coffee are widely consumed beverages worldwide. We evaluated their association with biliary tract cancer (BTC) incidence.We pooled data from 15 studies in the Biliary Tract Cancers Pooling Project to evaluate associations between tea and coffee consumption and biliary tract cancer development. We categorized participants as nondrinkers (0 cup/day), moderate drinkers (>0 and <3 cups/day), and heavy drinkers (≥3 cups/day). We estimated multivariable HRs and 95% CIs using Cox models. During 29,911,744 person-years of follow-up, 851 gallbladder, 588 intrahepatic bile duct, 753 extrahepatic bile duct, and 458 ampulla of Vater cancer cases were diagnosed. Individuals who drank tea showed a statistically significantly lower incidence rate of gallbladder cancer (GBC) relative to tea nondrinkers (HR=0.77; 95% CI, 0.64-0.91), and intrahepatic bile duct cancer (IHBDC) had an inverse association (HR=0.81; 95% CI, 0.66-1.00). However, no associations were observed for extrahepatic bile duct cancer (EHBDC) or ampulla of Vater cancer (AVC). In contrast, coffee consumption was positively associated with GBC, with a higher incidence rate for individuals consuming more coffee (HR<3 cups/day =1.29; 95% CI, 1.01-1.66; HR≥3 cups/day =1.49; 95% CI, 1.11-1.99, Ptrend=0.01) relative to coffee nondrinkers. However, there was no association between coffee consumption and GBC when restricted to coffee drinkers. There was little evidence of associations between coffee consumption and other biliary tract cancers.Tea consumption was associated with a lower incidence of GBC and possibly IHBDC. Further research is warranted to replicate the observed positive association between coffee and GBC.Copyright © 2023 American Association for the Study of Liver Diseases.