化疗 (CT) 仍然是引起持续性周围神经病变 (CIPN) 的上皮性卵巢癌 (EOC) 的主要治疗方法。本研究使用专用的患者报告结果工具，在长期 EOC 幸存者队列中调查了持续性 CIPN 及其药物遗传学预测因子。Vivrovaire 是法国多中心队列，受试者为 CT 完成 3 年后无疾病的 EOC 患者。使用 FACT/GOG-Ntx4 自我问卷评估持续 CIPN。评估了选定基因中纯合 (hom) 或杂合 (het) 单核苷酸多态性 (SNP) 的关联。纳入了 130 名患者，CT 完成后的中位时间为 63 [35-180] 个月。 CIPN 评分中位数为 37 [18-44]，其中 35 名 (26.9%) 患者报告严重 CIPN (<33)。 SNP 鉴定如下：CYP2C8 [hom，n = 32 (24.6%)/het，n = 99，(76.2%)]； CYP3A4 [hom，n = 0 (0%)/het，n = 8 (6.2%)]、ERCC1 [hom，n = 21 (16.2%)/het，n = 57 (43.8%)] 和 XPC [hom，n = 21 (16.2%)/het，n = 57 (43.8%)] ，n = 45 (34.6%)/het，n = 66 (50.8%)]。在单变量分析中，≥1 hom SNP 的识别与较低的 CIPN 评分相关（连续变量；p = 0.045）。携带 hom 或 het CYP2C8_rs1934951 SNP 的患者报告更有可能出现严重 CIPN（阈值 <33）评分（OR 2.482；95% CI [1.126-5.47]，p = 0.024）。在多变量分析中，年龄、CT 完成间隔、CT 疗程类型和次数与 CIPN 评分没有显着相关性（OR 5.165，95% CI [0.478-55.83]，p = 0.176）。持续性 CIPN 在卵巢癌中很常见长期幸存者。 CYP2C8_rs1934951 SNP 可能与 EOC 幸存者的严重残留 CIPN 相关。需要进行更多研究来确定 CIPN 的预测因素。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Chemotherapy (CT) remains a backbone treatment of epithelial ovarian cancer (EOC) inducing persistent peripheral neuropathy (CIPN). Using a dedicated patient-reported outcome tool, this study investigated persistent CIPN and its pharmacogenetic predictors in a cohort of long-term EOC survivors.Vivrovaire was a French multicenter cohort of patients with EOC free of disease 3 years after CT completion. Persistent CIPN was assessed using the FACT/GOG-Ntx4 self-questionnaire. The association of homozygous (hom) or heterozygous (het) single nucleotide polymorphisms (SNPs) in selected genes was evaluated.130 patients were included with a median time from CT completion of 63 [35-180] months. The median CIPN score was 37 [18-44], with 35 (26.9%) patients reporting severe CIPN (<33). SNPs were identified as follows: CYP2C8 [hom, n = 32 (24.6%)/het, n = 99, (76.2%)]; CYP3A4 [hom, n = 0 (0%)/het, n = 8 (6.2%)], ERCC1 [hom, n = 21 (16.2%)/het, n = 57 (43.8%)], and XPC [hom, n = 45 (34.6%)/het, n = 66 (50.8%)]. In univariate analysis, the identification of ≥1 hom SNP was associated with a lower CIPN score (continuous variable; p = 0.045). Patients harboring hom or het CYP2C8_rs1934951 SNP reported more likely severe CIPN (threshold <33) score (OR 2.482; 95% CI [1.126-5.47], p = 0.024). In the multivariate analyses, age, interval from CT completion, type and number of CT courses were not significantly associated with CIPN score (OR 5.165, 95% CI [0.478-55.83], p = 0.176).Persistent CIPN is common among ovarian cancer long-term survivors. CYP2C8_rs1934951 SNP may be associated with severe residual CIPN in EOC survivors. More studies are warranted to identify predictive factors of CIPN.Copyright © 2024 Elsevier Inc. All rights reserved.