研究动态
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教育和心理生存干预措施对改善接受雄激素剥夺治疗的前列腺癌男性健康相关生活质量的有效性:系统评价。

Effectiveness of educational and psychological survivorship interventions to improve health-related quality of life outcomes for men with prostate cancer on androgen deprivation therapy: a systematic review.

发表日期:2024 May 22
作者: Sally Am Sara, Nicole Heneka, Anna Green, Suzanne K Chambers, Jeff Dunn, Victoria R Terry
来源: PHARMACOLOGY & THERAPEUTICS

摘要:

雄激素剥夺疗法 (ADT) 是前列腺癌的常见治疗方法,会对身体和心理生活质量产生严重影响。虽然一些干预措施侧重于管理 ADT 的身体副作用,但同时满足社会心理和教育需求的干预措施却很少。本系统评价的目的是确定针对 ADT 男性健康相关生活质量 (HRQoL) 结果的心理和教育生存干预措施。随机对照试验的系统评价。Web of Science、Cochrane、EBSCO Host、PubMed、SCOPUS从成立(1984年)到2023年1月28日。针对接受ADT的男性的HRQoL结果的心理和/或教育生存干预措施;至少 80% 的参与者接受 ADT;使用经过验证的 HRQoL 结果测量;在同行评审期刊上以英文发表。使用预先指定的研究标准进行数据提取。符合条件的研究的异质性妨碍了荟萃分析。总共确定了 3381 篇出版物,其中 8 篇符合标准。干预措施要么是心理干预,采用认知行为方法 (n = 4),要么是教育干预,包括 (n = 2) 或不包括 (n = 2) 心理教育成分。两项研究报告,使用特定的 HRQoL 测量方法取得了统计学上的显着改善。大多数研究没有足够的动力和/或样本量较小,限制了可以得出的有效性结论。最有效的干预措施是(i)以个人为基础,(ii)包含心理教育成分的教育,(iii)补充信息包和/或家庭作业,以及(iv)包括个性化需求评估。报告心理和教育的文献很少针对 ADT 男性 HRQoL 结果的生存干预。迫切需要的是以人为本的生存干预措施,这些干预措施足够灵活,能够识别和满足个人需求,同时考虑到 ADT 对身心生活质量的影响。CRD4202230809.© 作者(或其雇主) )) 2024。根据 CC BY-NC 允许重复使用。不得商业再利用。请参阅权利和权限。英国医学杂志出版。
Androgen deprivation therapy (ADT), a common treatment for prostate cancer, has debilitating impacts on physical and psychological quality of life. While some interventions focus on managing the physical side effects of ADT, there is a paucity of interventions that also address psychosocial and educational needs. The objective of this systematic review was to identify psychological and educational survivorship interventions targeting health-related quality of life (HRQoL) outcomes in men on ADT.A systematic review of randomised controlled trials.Web of Science, Cochrane, EBSCO Host, PubMed, SCOPUS from inception (1984) to 28 January 2023.Psychological and/or educational survivorship interventions targeting HRQoL outcomes for men on ADT; minimum 80% of participants on ADT; used a validated HRQoL outcome measure; published in English in a peer-reviewed journal.Data extraction using pre-specified study criteria was conducted. Heterogeneity of eligible studies precluded a meta-analysis.A total of 3381 publications were identified with eight meeting the criteria. Interventions were either psychological with a cognitive behavioural approach (n=4), or educational with (n=2) or without (n=2) psychoeducational components.Two studies reported a statistically significant improvement using a specific HRQoL measure. Most studies were not adequately powered and/or included small sample sizes limiting the conclusions that can be drawn on effectiveness. The most effective interventions were (i) individually based, (ii) educational with a psychoeducational component, (iii) supplemented with information packages and/or homework and (iv) included personalised needs assessments.There is a paucity of literature reporting psychological and educational survivorship interventions targeting HRQoL outcomes for men on ADT. What is urgently needed are person-centred survivorship interventions that are flexible enough to identify and address individual needs, taking into account the impact ADT has on both physical and psychological quality of life.CRD4202230809.© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.