骨关节炎是最常见的与年龄相关的退行性关节疾病，也是老年人疼痛和残疾的主要原因。其病因是多方面的，涉及生物力学、促炎介质、遗传学和代谢等因素。除了对关节功能的明显影响和对患者生活质量的侵蚀之外，骨关节炎还与各种全身性疾病表现出共生关系，导致各种并发症。这篇综述揭示了 OA 的广泛影响，包括骨质疏松症、肌肉减少症、心血管疾病、糖尿病、神经系统疾病、心理健康，甚至癌症。共同的炎症过程、遗传因素和生活方式因素将 OA 与这些全身性疾病联系起来。因此，认识到这些联系并解决它们为加强患者护理和减轻相关疾病负担提供了机会，强调需要采取整体方法来管理 OA 及其并发症。版权所有 © 2024 Li、Yang、Li、Zhang、Li 和 Lv 。

Osteoarthritis is the most prevalent age-related degenerative joint disease and a leading cause of pain and disability in aged people. Its etiology is multifaceted, involving factors such as biomechanics, pro-inflammatory mediators, genetics, and metabolism. Beyond its evident impact on joint functionality and the erosion of patients' quality of life, OA exhibits symbiotic relationships with various systemic diseases, giving rise to various complications. This review reveals OA's extensive impact, encompassing osteoporosis, sarcopenia, cardiovascular diseases, diabetes mellitus, neurological disorders, mental health, and even cancer. Shared inflammatory processes, genetic factors, and lifestyle elements link OA to these systemic conditions. Consequently, recognizing these connections and addressing them offers opportunities to enhance patient care and reduce the burden of associated diseases, emphasizing the need for a holistic approach to managing OA and its complications.Copyright © 2024 Li, Yang, Li, Zhang, Li and Lv.