Pristimerin 是从威瑟科植物南蛇藤和梅登伍德植物中分离出来的天然三萜类化合物，具有抗炎、杀虫、抗菌和抗病毒物质，具有心脏保护和抗肿瘤作用以及骨质疏松症的治疗。这些特性解释了Pristimerin对不同类型肿瘤和其他疾病的治疗作用。越来越多的研究表明普斯蒂莫林具有广泛的生物活性，在现代医学和中医学的各个领域都显示出巨大的潜力。虽然Pristimerin广泛的药理作用已被其他人广泛研究，但我们的综合综述表明，其作用机制可能是通过影响基本细胞事件，包括阻断细胞周期、诱导细胞凋亡和自噬、抑制细胞迁移和侵袭，或通过激活或抑制多种细胞信号传导通路中的某些关键分子，包括核因子 κB (NF-κB)、磷脂酰肌醇 3-激酶/蛋白激酶 B/哺乳动物靶向大霉素 (PI3K/Akt/mTOR)、丝裂原激活蛋白激酶 ( MAPKs)、细胞外信号调节蛋白激酶 1/2 (ERK1/2)、Jun 氨基末端激酶 (JNK1/2/3)、活性氧 (ROS)、wingless/整合素 1 (Wnt)/β-连环蛋白，以及其他信号通路。本文综述了近年来Pristimerin药理作用机制的研究进展，以期为Pristimerin的分子靶向治疗及进一步开发利用提供理论依据。它还提供了对临床患者改进治疗和治疗方法的见解，以及探索普里替莫林作为治疗潜在方面的必要性。© 2024 Sun 等人。

Pristimerin, a natural triterpenoid isolated from the plants of southern snake vine and Maidenwood in the family Weseraceae, is anti-inflammatory, insecticidal, antibacterial, and antiviral substance and has been used for its cardioprotective and antitumor effects and in osteoporosis treatment. These qualities explain Pristimerin's therapeutic effects on different types of tumors and other diseases. More and more studies have shown that pristimerin acts in a wide range of biological activities and has shown great potential in various fields of modern and Chinese medicine. While Pristimerin's wide range of pharmacological effects have been widely studied by others, our comprehensive review suggests that its mechanism of action may be through affecting fundamental cellular events, including blocking the cell cycle, inducing apoptosis and autophagy, and inhibiting cell migration and invasion, or through activating or inhibiting certain key molecules in several cell signaling pathways, including nuclear factor κB (NF-κB), phosphatidylinositol 3-kinase/protein kinase B/mammalian-targeted macromycin (PI3K/Akt/mTOR), mitogen-activated protein kinases (MAPKs), extracellular signal-regulated protein kinase 1/2 (ERK1/2), Jun amino-terminal kinase (JNK1/2/3), reactive oxygen species (ROS), wingless/integrin1 (Wnt)/β-catenin, and other signaling pathways. This paper reviews the research progress of Pristimerin's pharmacological mechanism of action in recent years to provide a theoretical basis for the molecular targeting therapy and further development and utilization of Pristimerin. It also provides insights into improved treatments and therapies for clinical patients and the need to explore pristimerin as a potential facet of treatment.© 2024 Sun et al.