作为肿瘤微环境的主要组成部分，间充质干细胞（MSC）和巨噬细胞都可以在肿瘤发生和进展过程中进行重塑并表现出不同的表型和功能。近年来，越来越多的证据表明，肿瘤相关巨噬细胞（TAM）在血液恶性肿瘤的生长、转移和化疗耐药中发挥着至关重要的作用，并与不良预后相关。因此，TAM 已成为有前途的治疗靶点。值得注意的是，间充质干细胞对调节巨噬细胞和粒细胞等免疫细胞功能发挥着深远的影响，从而在塑造肿瘤周围的免疫抑制微环境中发挥着至关重要的作用。然而，在血液恶性肿瘤中，间充质干细胞和巨噬细胞之间相互作用的细胞和分子机制尚未明确阐明。在这篇综述中，我们概述了 TAM 在各种常见血液恶性肿瘤中的作用，并讨论了了解 MSC 和巨噬细胞在疾病进展中相互作用的最新进展。此外，还概述了针对这种关系的潜在治疗方法。版权所有 © 2024 Li、Nie、Jin 和 Wu。

As major components of the tumor microenvironment, both mesenchymal stem cells (MSCs) and macrophages can be remodelled and exhibit different phenotypes and functions during tumor initiation and progression. In recent years, increasing evidence has shown that tumor-associated macrophages (TAMs) play a crucial role in the growth, metastasis, and chemotherapy resistance of hematological malignancies, and are associated with poor prognosis. Consequently, TAMs have emerged as promising therapeutic targets. Notably, MSCs exert a profound influence on modulating immune cell functions such as macrophages and granulocytes, thereby playing a crucial role in shaping the immunosuppressive microenvironment surrounding tumors. However, in hematological malignancies, the cellular and molecular mechanisms underlying the interaction between MSCs and macrophages have not been clearly elucidated. In this review, we provide an overview of the role of TAMs in various common hematological malignancies, and discuss the latest advances in understanding the interaction between MSCs and macrophages in disease progression. Additionally, potential therapeutic approaches targeting this relationship are outlined.Copyright © 2024 Li, Nie, Jin and Wu.