芳香酶抑制剂用于治疗乳腺癌，因为与他莫昔芬相比，其癌症复发率较低。然而，芳香酶抑制剂引起的关节痛（AIIA）是治疗不依从的主要原因之一，增加了癌症复发的风险。人们对 AIIA 的病理生理学知之甚少，尽管目前对 AIIA 的建议包括根据症状的严重程度改变生活方式和使用镇痛药，但尚无既定的有效治疗方法。本研究旨在探讨AIIA的表现和机制，探讨不同运动干预措施（有氧、抗阻、有氧与抗阻结合、瑜伽或太极拳）对AIIA患者的可行性和有效性，以指导AIIA患者正规运动的发展。运动处方指南。研究结果表明，有氧运动和抗阻运动的混合模式是可行且安全的，并且可能在改善关节疼痛、功能和生活质量方面发挥最大作用。更具体地说，每周的锻炼方案应包括 150 分钟的有氧运动，以及两次至少 6 次阻力练习，重复 8 至 12 次，每组 3 组。根据患者的目标症状，可能会建议每周两次补充瑜伽和太极拳。瑜伽与改善身体机能有关，而太极拳则与改善心理健康有关。然而，本次综述并未研究有氧运动和抗阻运动与瑜伽或太极拳相结合的方案在我们的目标人群中的可行性和影响。建议未来的研究使用大型随机对照试验。© 2024 作者。下午

Aromatase inhibitors are prescribed in breast cancer due to their associated lower rate of cancer recurrence compared to tamoxifen. However, aromatase inhibitor-induced arthralgia (AIIA) is one of the leading causes of treatment nonadherence, increasing the risk of cancer recurrence. The pathophysiology of AIIA is poorly understood, and although current recommendations for AIIA include lifestyle changes and analgesics depending on the severity of symptoms, there is no established effective treatment. The aim of this study is to explore the presentation and mechanism of AIIA and investigate the feasibility and efficacy of different exercise interventions (aerobic, resistance, aerobic and resistance combined, and yoga or tai chi) in patients with AIIA to guide the development of formal exercise prescription guidelines. Findings indicate that a mixed-modality regimen of aerobic and resistance exercises is feasible and safe and may serve the most benefit in improving joint pain, functionality, and quality of life. More specifically, the weekly regimen should consist of 150 min of aerobic exercise with two sessions of at least six resistance exercises, 8 to 12 repetitions, three sets each. Supplementary yoga and tai chi may be recommended twice a week depending on a patient's target symptoms. Yoga was associated with improved physical functionality, whereas tai chi was related to improvements in mental health. However, the feasibility and impact of combined aerobic and resistance exercise protocols with yoga or tai chi in our target population were not investigated in this review. The use of large, randomized controlled trials is recommended for future studies.© 2024 The Authors. PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation.