结直肠癌手术后肺部并发症的危险因素:日本多中心研究。
Risk factors for pulmonary complications after colorectal cancer surgery: a Japanese multicenter study.
发表日期:2024 May 23
作者:
Tetsuro Tominaga, Takashi Nonaka, Yuma Takamura, Kaido Oishi, Shintaro Hashimoto, Toshio Shiraishi, Keisuke Noda, Rika Ono, Mitsutoshi Ishii, Makoto Hisanaga, Hiroaki Takeshita, Hidetoshi Fukuoka, Shosaburo Oyama, Kazuhide Ishimaru, Masaki Kunizaki, Terumitsu Sawai, Keitaro Matsumoto
来源:
PHARMACOLOGY & THERAPEUTICS
摘要:
肺部并发症 (PC) 是一种严重疾病,死亡率为 20%。然而,很少有报告研究结直肠手术后 PC 的危险因素。本研究调查了结直肠癌手术后 PC 的频率、特征和危险因素。2016 年 1 月至 2022 年 12 月,我们回顾性分析了 7 家参与医院连续 3979 名接受结直肠癌手术的患者。将患者分为经历过 PC 的患者(PC 组,n = 54)和未经历过 PC 的患者(非 PC 组,n = 3925)。比较各组的临床和病理特征。54例患者(1.5%)发生PC,其中2例(3.7%)因PC死亡。年龄较大(80 岁 vs 71 岁;p< 0.001),慢性阻塞性肺窘迫的频率较高(9.3% vs 3.2%;p= 0.029),体能状态较差(p< 0.001),体重不足的比例PC 中的比例较高(42.6% vs 13.4%,p< 0.001),开放手术频率较高(24.1% vs 9.3%;p< 0.001),失血量较多(40 mL vs 22 mL;p< 0.001)团体。多变量分析显示男性(优势比 (OR) 2.165,95% 置信区间 (CI) 1.176-3.986;p = 0.013)、年龄较大(OR 3.180,95%CI 1.798-5.624;p < 0.001)、体重不足(OR 3.961,95%CI 2.210-7.100;p< 0.001)和较差的 ASA-PS(OR 3.828,95%CI 2.144-6.834;p< 0.001)是 PC 的独立预测因素。我们的研究显示男性、年龄较大、体重不足和较差的 ASA-PS 是与 PC 发展相关的因素,并建议对 PC 高危患者实施术前和术后康复和肺炎控制措施。© 2024。作者。
Pulmonary complications (PC) are a serious condition with a 20% mortality rate. However, few reports have examined risk factors for PC after colorectal surgery. This study investigated the frequency, characteristics, and risk factors for PC after colorectal cancer surgery.Between January 2016 and December 2022, we retrospectively reviewed 3979 consecutive patients who underwent colorectal cancer surgery in seven participating hospitals. Patients were divided into patients who experienced PC (PC group, n = 54) and patients who did not (non-PC group, n = 3925). Clinical and pathological features were compared between groups.Fifty-four patients (1.5%) developed PC, of whom 2 patients (3.7%) died due to PC. Age was greater (80 years vs 71 years; p < 0.001), frequency of chronic obstructive pulmonary distress was greater (9.3% vs 3.2%; p = 0.029), performance status was poorer (p < 0.001), the proportion of underweight was higher (42.6% vs 13.4%, p < 0.001), frequency of open surgery was greater (24.1% vs 9.3%; p < 0.001), and blood loss was greater (40 mL vs 22 mL; p < 0.001) in the PC group. Multivariate analysis revealed male sex (odds ratio (OR) 2.165, 95% confidence interval (CI) 1.176-3.986; p = 0.013), greater age (OR 3.180, 95%CI 1.798-5.624; p < 0.001), underweight (OR 3.961, 95%CI 2.210-7.100; p < 0.001), and poorer ASA-PS (OR 3.828, 95%CI 2.144-6.834; p < 0.001) as independent predictors of PC.Our study revealed male sex, greater age, underweight, and poorer ASA-PS as factors associated with development of PC, and suggested that pre- and postoperative rehabilitation and pneumonia control measures should be implemented for patients at high risk of PC.© 2024. The Author(s).