掌跖红肿感觉 (PPE) 是一种缓慢发展的皮肤反应，常见于接受氟嘧啶治疗的患者。虽然红肿感觉通常呈掌跖分布，但也可能累及生殖器，但这种表现可能被低估，并被错误地归因于放射治疗的急性反应。本文旨在将阴茎和阴囊红肿感觉定义为卡培他滨的一种罕见但显着的副作用。我们在 2 年内在一家大型三级癌症中心发现了 5 例中度至重度阴茎和阴囊红肿感觉，代表了估计的发病率在我们机构内接受基于氟嘧啶的放化疗的男性直肠癌患者中，这一比例为 3.6%。 提高对涉及阴茎和阴囊的红肿感觉的了解有助于早期识别和治疗症状，并可能防止癌症治疗的中断或延迟。接受卡培他滨和类似药物治疗的患者。这些临床进展将改善和延长癌症治疗期间患者的生活质量，并预防导致住院的并发症。© 2024。作者。

Palmar-plantar erythrodysesthesia (PPE) is a slowly developing cutaneous reaction commonly experienced by patients treated with fluoropyrimidines. While erythrodysesthesia normally presents in a palmar-plantar distribution, it can also present with genital involvement, but this presentation is likely underreported and incorrectly attributed to an acute reaction from radiation therapy. This article aims to define erythrodysesthesia of the penis and scrotum as a rare but significant side effect of capecitabine.We identified five cases of moderate to severe penis and scrotal erythrodysesthesia over a 2-year period at a large tertiary cancer center, representing an estimated incidence of 3.6% among male patients with rectal cancer who were treated with fluoropyrimidine-based chemoradiation within our institution.Improved understanding of erythrodysesthesia involving the penis and scrotum can facilitate early identification and treatment of symptoms, and possibly prevent the discontinuation or delay of cancer treatment in patients treated with capecitabine and similar drugs. These clinical advances would improve and prolong patient quality of life during cancer treatment and prevent complications that result in hospitalization.© 2024. The Author(s).