皮肤病患者的抗带状疱疹疫苗接种:意大利性传播、传染病和热带疾病 SIDeMaST 小组的立场声明。
Anti-Herpes zoster vaccination in patients with dermatologic diseases: a position statement from the Italian SIDeMaST group of sexually transmitted, infectious and tropical diseases.
发表日期:2024 May 23
作者:
Giulia Ciccarese, Francesco Drago, Astrid Herzum, Laura Atzori, Annunziata Dattola, Marco Galluzzo, Carlo Maronese, Annalisa Patrizi, Bianca M Piraccini, Sebastiano Recalcati, Maria C Fargnoli, Angelo V Marzano, Manuela Papini
来源:
TROPICAL MEDICINE & INTERNATIONAL HEALTH
摘要:
带状疱疹 (HZ) 是由水痘带状疱疹病毒 (VZV) 重新激活引起的疾病,水痘带状疱疹病毒是导致水痘的病毒,水痘是原发感染的临床表现。先天性或后天性免疫系统缺陷,以及老年人发生的免疫反应的生理性下降(称为免疫衰老),都可能导致 VZV 重新激活,从而导致带状疱疹。三分之一的人在一生中患有带状疱疹。此外,百分之三十的受影响受试者会出现带状疱疹后神经痛,这是带状疱疹皮疹后最常见的并发症。患有以免疫系统改变为特征的皮肤病的患者,例如系统性红斑狼疮、牛皮癣、特应性皮炎、大疱性疾病和皮肤淋巴瘤,即使疾病处于缓解期,发生带状疱疹和带状疱疹后神经痛的风险也较高。在目前的工作中,我们描述了目前可用的带状疱疹疫苗,并为皮肤病患者的带状疱疹疫苗接种提供了建议。
Herpes zoster (HZ) is a condition caused by the reactivation of varicella-zoster virus (VZV), the virus responsible for chickepox, which is the clinical manifestation of the primary infection. Congenital or acquired immune system deficiencies, as well as the physiological decline in immune response occurring in the elderly, known as immune senescence, can allow VZV reactivation and, consequently, HZ. One out of 3 people develops HZ during their lifetime. Moreover, thirty percent of the affected subjects develop post-herpetic neuralgia, the most frequent complication after HZ skin rash. Patients with dermatological conditions characterized by alteration of the immune system, such as systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous diseases, and cutaneous lymphomas, are at higher risk of developing HZ and post-herpetic neuralgia, even when their disease is in remission. In the present work, we described the currently available vaccinations against HZ and provided recommendations for the vaccination against HZ in patients with dermatological diseases.