作者努力提高日间化疗科的肿瘤治疗能力，同时允许工作人员治疗更多患者并为患者提供更大的灵活性，这增加了作者信托无菌药房的压力。因此，探索了护士主导的药物制备的可能性。试点了护士主导的单克隆抗体（MAb）制备，以研究减少对无菌药房的依赖是否可以与维持最佳治疗能力并存。还探讨了封闭系统转移装置 (CSTD) 保护护士免受药物暴露的有效性。考虑用于护士主导的准备的 MAb 风险评估已创建，同时还制定了安全处理全身抗癌治疗的程序 (SACT) ）通过使用 CSTD。该试点项目使患者等待单克隆抗体准备的时间减少了 89%。新程序中纳入了七种肿瘤药物，但不会增加护士的接触风险。该试点成功减少了对无菌药房的需求，同时实现了日间化疗病房容量的有效利用。 CSTD 的使用最大限度地降低了护士接触 SACT 的风险。

Efforts to increase capacity for oncology treatment in the author's Chemotherapy Day Unit, while allowing staff to treat more patients and offer more flexibility to patients, increased strain on the Aseptic Pharmacy at the author's Trust. Therefore, the possibility of nurse-led drug preparation was explored.Nurse-led monoclonal antibody (MAb) preparation was piloted to investigate whether a reduction in reliance on Aseptic Pharmacy could co-exist with maintaining optimal treatment capacity. The effectiveness of a closed system transfer device (CSTD) to protect nurses against drug exposure was also explored.A risk assessment for MAbs considered for nurse-led preparation was created, alongside a procedure for the safe handling of systemic anti-cancer therapy (SACT) with the use of a CSTD.The pilot resulted in an 89% reduction in the time patients had to wait for MAbs to be prepared. Seven oncology drugs were included in the new procedure without increasing the risk of exposure for nurses.The pilot successfully reduced demand on Aseptic Pharmacy while enabling efficient capacity use on the Chemotherapy Day Unit. The use of the CSTD minimised the risk of nurse exposure to SACT.