胰腺导管腺癌 (PDA) 是一种具有挑战性的疾病，处于晚期阶段，会导致许多症状，对患者的生活质量产生负面影响并降低他们接受有效治疗的能力。对早期和晚期疾病尽早实施专家多学科护理，包括营养支持、运动和姑息治疗，有望维持或改善患者的身体、社会和心理健康，减少临终时的积极干预，并最终提高生存率。此外，新辅助和转移治疗策略的进步与针对疾病关键驱动因素的新型治疗药物相结合，正在改善胰腺癌患者的护理。在这里，我们强调对PDA患者的多学科支持和治疗护理，回顾局部疾病的新辅助和围手术期治疗的现行指南和新进展，以及晚期PDA的治疗标准和精准肿瘤学和免疫治疗领域的发展。

Pancreatic ductal adenocarcinoma (PDA) is a challenging disease that presents at an advanced stage and results in many symptoms that negatively influence patients' quality of life and reduce their ability to receive effective treatment. Early implementation of expert multidisciplinary care with nutritional support, exercise, and palliative care for both early-stage and advanced disease promises to maintain or improve the patients' physical, social, and psychological well-being, decrease aggressive interventions at the end of life, and ultimately improve survival. Moreover, advances in treatment strategies in the neoadjuvant and metastatic setting combined with novel therapeutic agents targeting the key drivers of the disease are leading to improvements in the care of patients with pancreatic cancer. Here, we emphasize the multidisciplinary supportive and therapeutic care of patients with PDA, review current guidelines and new developments of neoadjuvant and perioperative treatments for localized disease, as well as the treatment standards and the evolving field of precision oncology and immunotherapies for advanced PDA.