以防御为导向的炎症反应有助于年轻时的生存，但可能会导致现代老龄化社会的健康损害。 IL-1 细胞因子是高度保守和受调节的多效性炎症介质，对于充分应对感染和组织损伤至关重要，但如果不解决，也可能对宿主产生损害。在这篇综述中，我们讨论了持续的低水平 IL-1 信号传导如何导致与衰老相关的造血干细胞和祖细胞 (HSPC) 功能损伤，以及这种炎症选择压力如何驱动更深远的血液学改变，例如克隆造血作用不确定电位（CHIP），以及明显的 HSPC 疾病，如骨髓增殖性和骨髓增生异常性肿瘤以及急性髓系白血病。基于此，我们概述了如何利用 IL-1 通路抑制来预防或治疗“炎症衰老”相关的 HSPC 病理。版权所有 © 2024 美国血液学会。

Defense-oriented inflammatory reactivity supports survival at younger age, but might contribute to health impairments in modern, aging societies. The IL-1 cytokines are highly conserved and regulated, pleiotropic mediators of inflammation, essential to respond adequately to infection and tissue damage, but also with potential host damaging effects when left unresolved. In this review, we discuss how continuous low-level IL-1 signaling contributes to aging-associated hematopoietic stem and progenitor cell (HSPC) functional impairments and how this inflammatory selective pressure acts as a driver of more profound hematological alterations, such as clonal hematopoiesis of indeterminate potential (CHIP), and to overt HSPC diseases, like myeloproliferative and myelodysplastic neoplasia as well as acute myeloid leukemia. Based on this, we outline how IL-1 pathway inhibition might be utilized to prevent or treat "inflamm-aging" associated HSPC pathologies.Copyright © 2024 American Society of Hematology.