最近的报告表明，接触苯可能与实体癌有关，例如肺癌和膀胱癌。相反，关于苯与结直肠癌 (CRC) 之间关联的证据很少。因此，我们的目的是总结有关职业苯暴露与结直肠癌之间关系的现有文献。我们检索了 Pubmed、Embase（通过 Ovid）和 Scopus，以检索关于职业苯暴露与实体癌之间关联的队列和巢式病例对照研究。该检索最初于 2022 年 12 月完成，后来于 2024 年 4 月更新。我们使用纽卡斯尔-渥太华量表的修改版本评估了纳入研究的质量。我们根据职业苯暴露，使用 Paule-Mandel 方法计算了 CRC 的汇总相对风险 (RR) 和相应的 95% 置信区间 (CI)。荟萃分析中纳入了 28 项研究。其中大多数是在欧洲或北美进行的（82.1%）并且是基于行业的（89.3%）。比较接触苯的工人与未接触苯的工人的发病率和死亡率的汇总 RR 分别为 1.10 (95% CI: 1.06, 1.15) 和 1.04 (95% CI: 0.97, 1.11)，CRC 为 1.12 (95% CI: 1.01, 1.24)对于结肠癌，分别为 1.08 (95% CI: 0.99, 1.19)；对于直肠癌，分别为 1.04 (95% CI: 0.94, 1.14) 和 1.05 (95% CI: 0.92, 1.19)。只有一项研究支持职业苯暴露与结直肠癌之间存在剂量反应关系，而其他研究则发现风险并未因暴露剂量或工作时间而增加。我们的研究结果表明职业苯暴露可能与结直肠癌有关。有必要对个人水平暴露进行进一步研究和详细评估来确认我们的结果。版权所有 © 2024。由 Elsevier Inc. 出版。

Recent reports suggest that benzene exposure may be associated with solid cancers, such as lung and bladder cancers. Instead, evidence on the association between benzene and colorectal cancer (CRC) is sparse. Thus, we aimed to summarize current literature on the association between occupational benzene exposure and CRC. We searched Pubmed, Embase (through Ovid), and Scopus to retrieve cohort and nested case-control studies on the association between occupational benzene exposure and solid cancers. The search was initially completed in December 2022 and later updated in April 2024. We assessed quality of included studies using a modified version of Newcastle-Ottawa Scale. We computed pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) of CRC according to occupational benzene exposure, using the Paule-Mandel method. Twenty-eight studies were included in the meta-analysis. Most of them were conducted in Europe or North America (82.1%) and were industry-based (89.3%). Pooled RRs comparing workers exposed to benzene with those who were unexposed for incidence and mortality were 1.10 (95% CI: 1.06, 1.15) and 1.04 (95% CI: 0.97, 1.11) for CRC, 1.12 (95% CI: 1.01, 1.24) and 1.08 (95% CI: 0.99, 1.19) for colon cancer, and 1.04 (95% CI: 0.94, 1.14) and 1.05 (95% CI: 0.92, 1.19) for rectal cancer, respectively. Only one study supported the occurrence of a dose-response relationship between occupational benzene exposure and CRC, while others found no increase in risk according to dose of exposure or duration of employment. Our findings suggest that occupational benzene exposure may be associated with CRC. Further research with detailed assessment of individual-level exposure is warranted to confirm our results.Copyright © 2024. Published by Elsevier Inc.