多形性胶质母细胞瘤 (GBM) 是最具侵袭性的脑肿瘤，平均预期寿命不到 15 个月。 GBM 患者如此高的死亡率与各种遗传和表观遗传改变导致的临床和分子异质性有关。极其重要的信号传导途径的这种改变归因于异常的基因信号传导。 GBM 的不同亚类显示出不同遗传改变的优势，因此，了解 GBM 不同亚类中复杂的信号通路及其关键分子成分对于临床管理极为重要。在本书章节中，我们总结了在不同亚类中发挥重要作用的常见且重要的信号通路，并从临床前研究和临床试验方面讨论了它们的治疗靶向方法。版权所有 © 2024。由爱思唯尔公司出版。

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with an average life expectancy of less than 15 months. Such high patient mortality in GBM is pertaining to the presence of clinical and molecular heterogeneity attributed to various genetic and epigenetic alterations. Such alterations in critically important signaling pathways are attributed to aberrant gene signaling. Different subclasses of GBM show predominance of different genetic alterations and therefore, understanding the complex signaling pathways and their key molecular components in different subclasses of GBM is extremely important with respect to clinical management. In this book chapter, we summarize the common and important signaling pathways that play a significant role in different subclasses and discuss their therapeutic targeting approaches in terms of preclinical studies and clinical trials.Copyright © 2024. Published by Elsevier Inc.