越来越多的证据表明，肿瘤相关巨噬细胞丰度的增加通常与结直肠癌（CRC）的不良预后相关。肿瘤源性外泌体对 M2 巨噬细胞极化影响的机制仍不清楚。新型环状 RNA circPOLQ 在 CRC 组织中的表达显着高于配对的正常组织。 circPOLQ 表达较高与 CRC 患者预后较差相关。体外和体内实验表明，肿瘤来源的外泌体circPOLQ并不直接调节CRC细胞的发育，而是通过增强M2巨噬细胞极化来促进CRC转移结节的形成。 circPOLQ通过靶向miR-379-3 p激活白细胞介素10/信号转导子和转录3轴激活子，促进M2巨噬细胞极化。circPOLQ可以通过CRC细胞来源的外泌体进入巨噬细胞，并通过增强M2巨噬细胞极化促进CRC转移结节形成。这些发现揭示了肿瘤源性外泌体介导的肿瘤-巨噬细胞相互作用，可能影响 CRC 转移结节的形成。© 作者（或其雇主）2024。根据 CC BY-NC 允许重复使用。禁止商业再利用。请参阅权利和权限。由英国医学杂志出版。

Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 macrophage polarization remains elusive.The novel circular RNA circPOLQ exhibited significantly higher expression in CRC tissues than in paired normal tissues. Higher circPOLQ expression was associated with poorer prognosis in patients with CRC. In vitro and in vivo experiments showed that tumor-derived exosomal circPOLQ did not directly regulate CRC cell development but promoted CRC metastatic nodule formation by enhancing M2 macrophage polarization. circPOLQ activated the interleukin-10/signal transducer and activator of transcription 3 axis by targeting miR-379-3 p to promote M2 macrophage polarization.circPOLQ can enter macrophages via CRC cell-derived exosomes and promote CRC metastatic nodule formation by enhancing M2 macrophage polarization. These findings reveal a tumor-derived exosome-mediated tumor-macrophage interaction potentially affecting CRC metastatic nodule formation.© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.