仿生膜材料在中枢神经系统疾病中的应用及进展。
Application and advances of biomimetic membrane materials in central nervous system disorders.
发表日期:2024 May 23
作者:
Weiquan Liao, Zhichao Lu, Chenxing Wang, Xingjia Zhu, Yang Yang, Youlang Zhou, Peipei Gong
来源:
JOURNAL OF NANOBIOTECHNOLOGY
摘要:
中枢神经系统 (CNS) 疾病包括脊髓损伤、脑肿瘤、神经退行性疾病和缺血性中风。最近,全球越来越多地认识到中枢神经系统疾病是人类残疾和死亡的主要原因,也是全球第二大常见死因。在全球人口迅速增长和人口老龄化的背景下,中枢神经系统疾病带来的全球负担和治疗挑战尤为重要。血脑屏障(BBB)对中枢神经系统疾病的有效药物输送提出了挑战,因为传统药物对大脑的渗透通常有限。仿生膜纳米材料技术的进步显示出利用天然生物表面、高生物相容性和生物安全性等特性,有望增强各种中枢神经系统疾病的药物输送。本文讨论了仿生膜材料的最新进展,总结了这些材料的类型和制备方法,分析了它们在治疗中枢神经系统损伤中的应用,并展望了仿生膜材料的未来前景和局限性。© 2024。 。
Central nervous system (CNS) diseases encompass spinal cord injuries, brain tumors, neurodegenerative diseases, and ischemic strokes. Recently, there has been a growing global recognition of CNS disorders as a leading cause of disability and death in humans and the second most common cause of death worldwide. The global burdens and treatment challenges posed by CNS disorders are particularly significant in the context of a rapidly expanding global population and aging demographics. The blood-brain barrier (BBB) presents a challenge for effective drug delivery in CNS disorders, as conventional drugs often have limited penetration into the brain. Advances in biomimetic membrane nanomaterials technology have shown promise in enhancing drug delivery for various CNS disorders, leveraging properties such as natural biological surfaces, high biocompatibility and biosafety. This review discusses recent developments in biomimetic membrane materials, summarizes the types and preparation methods of these materials, analyzes their applications in treating CNS injuries, and provides insights into the future prospects and limitations of biomimetic membrane materials.© 2024. The Author(s).