为了解决动物测试的局限性，科学研究越来越注重开发替代测试方法。这些替代测试利用来自动物或人类的细胞或组织以及人造组织和类器官进行体外测试。在西方国家，化妆品的动物试验已被禁止，导致采用人造皮肤进行毒性评估，例如皮肤腐蚀和刺激评估。皮肤类器官技术的标准指南变得必要，以确保用体外方法替代动物测试时数据和评估的一致性。这些指南涵盖细胞来源、培养技术、质量要求和评估、储存和保存以及基于类器官的检测等方面。

To address the limitations of animal testing, scientific research is increasingly focused on developing alternative testing methods. These alternative tests utilize cells or tissues derived from animals or humans for in vitro testing, as well as artificial tissues and organoids. In western countries, animal testing for cosmetics has been banned, leading to the adoption of artificial skin for toxicity evaluation, such as skin corrosion and irritation assessments. Standard guidelines for skin organoid technology becomes necessary to ensure consistent data and evaluation in replacing animal testing with in vitro methods. These guidelines encompass aspects such as cell sourcing, culture techniques, quality requirements and assessment, storage and preservation, and organoid-based assays.