肺癌具有高转移性和耐药性。肺癌患者的预后较差，患者的生存机会很容易被忽视。铁死亡是2012年提出的一种程序性细胞死亡，它不同于细胞凋亡、坏死和自噬。铁死亡是一种新型的受调节细胞死亡，由铁依赖性脂质过氧化和随后的质膜破裂驱动。在肿瘤疾病治疗领域具有广阔的前景。目前多项研究表明，生物化合物可诱导肺癌细胞铁死亡，具有显着的抗癌作用，且具有安全性高、副作用小、耐药可能性小的优点。在这篇综述中，我们通过重点关注铁死亡及其机制，总结了用于治疗肺癌的生物化合物。此外，我们系统回顾了纳米技术与生物化合物相结合治疗肿瘤的研究现状，为靶向铁死亡途径和应用基于生物化合物的疗法提供了新的思路。版权所有 © 2024 梁，王，李，王，刘和李。

Lung cancer has high metastasis and drug resistance. The prognosis of lung cancer patients is poor and the patients' survival chances are easily neglected. Ferroptosis is a programmed cell death proposed in 2012, which differs from apoptosis, necrosis and autophagy. Ferroptosis is a novel type of regulated cell death which is driven by iron-dependent lipid peroxidation and subsequent plasma membrane ruptures. It has broad prospects in the field of tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis in lung cancer cells, which exhibits significant anti-cancer effects, and they have the advantages in high safety, minimal side effects, and less possibility to drug resistance. In this review, we summarize the biological compounds used for the treatment of lung cancer by focusing on ferroptosis and its mechanism. In addition, we systematically review the current research status of combining nanotechnology with biological compounds for tumor treatment, shed new light for targeting ferroptosis pathways and applying biological compounds-based therapies.Copyright © 2024 Liang, Wang, Li, Wang, Liu and Li.