简介：近年来，瞬时受体电位（TRP）通道与各种恶性肿瘤、耐药性和放疗耐药性的发生之间存在密切关联。因此，我们从多个角度研究了瞬时受体电位通道与宫颈癌的关系。方法：从 TCGA 数据库中获取患者的 mRNA 表达谱和基因变异。采用最小绝对收缩和选择算子（LASSO）回归方法筛选瞬时受体电位通道预后相关基因（TRG）中的关键基因，并根据关键基因的表达构建风险特征。进行了各种分析，以评估基于风险特征的预后意义、生物学功能、免疫浸润和免疫治疗反应。结果：我们的研究揭示了高风险组和低风险组在预后、肿瘤微环境、肿瘤突变负荷、免疫浸润和免疫治疗反应方面存在显着差异。高危组患者的预后较差，肿瘤微环境评分较低，对免疫治疗的反应降低，同时对特定靶向药物的敏感性增加。体外实验进一步表明，抑制瞬时受体电位通道可有效降低宫颈癌细胞的增殖、侵袭和迁移。讨论：本研究强调了瞬时受体电位通道在宫颈癌中的巨大潜力，强调了它们在预后预测和个性化治疗策略中的关键作用。 TRP 抑制剂与免疫疗法和靶向药物的结合可能为宫颈癌患者带来希望。版权所有 © 2024 Jiang、Lin、Wu、Zheng、Cui、Cai、Li、Zheng 和 Sun。

Introduction: In recent years, there has been a strong association between transient receptor potential (TRP) channels and the development of various malignancies, drug resistance, and resistance to radiotherapy. Consequently, we have investigated the relationship between transient receptor potential channels and cervical cancer from multiple angles. Methods: Patients' mRNA expression profiles and gene variants were obtained from the TCGA database. Key genes in transient receptor potential channel prognosis-related genes (TRGs) were screened using the least absolute shrinkage and selection operator (LASSO) regression method, and a risk signature was constructed based on the expression of key genes. Various analyses were performed to evaluate the prognostic significance, biological functions, immune infiltration, and response to immunotherapy based on the risk signature. Results: Our research reveals substantial differences between high and low-risk groups in prognosis, tumor microenvironment, tumor mutational load, immune infiltration, and response to immunotherapy. Patients in the high-risk group exhibited poorer prognosis, lower tumor microenvironment scores and reduced response to immunotherapy while showing increased sensitivity to specific targeted drugs. In vitro experiments further illustrated that inhibiting transient receptor potential channels effectively decreased the proliferation, invasion, and migration of cervical cancer cells. Discussion: This study highlights the significant potential of transient receptor potential channels in cervical cancer, emphasizing their crucial role in prognostic prediction and personalized treatment strategies. The combination of TRP inhibitors with immunotherapy and targeted drugs may offer promise for individuals affected by cervical cancer.Copyright © 2024 Jiang, Lin, Wu, Zheng, Cui, Cai, Li, Zheng and Sun.