间皮瘤是一种无法治愈的间皮癌，通常由接触石棉引起。石棉引起的炎症是间皮瘤发展的一个重要因素，遗传因素也在这种快速进展且难以治疗的恶性肿瘤的易感性中发挥着作用。因此，迫切需要新的方法来治疗间皮瘤并预防或减少这种致命疾病的总体发病率。在本研究视角中，我们回顾了石棉诱发间皮瘤的化学预防和癌症拦截进展的现状。我们讨论了用于这些研究的不同临床前小鼠模型以及可能成为间皮瘤预防潜在目标的炎症因子。综述了天然植物化学物质和合成制剂的初步研究。还介绍了之前在接触石棉人群中进行的临床化学预防试验的结果以及对未来试验的考虑因素。

Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive and treatment-resistant malignancy. Consequently, novel approaches are urgently needed to treat mesothelioma and prevent or reduce the overall incidence of this fatal disease. In this research perspective, we review the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. We discuss the different preclinical mouse models used for these investigations and the inflammatory factors that may be potential targets for mesothelioma prevention. Preliminary studies with naturally occurring phytochemicals and synthetic agents are reviewed. Results of previous clinical chemoprevention trials in populations exposed to asbestos and considerations regarding future trials are also presented.