这篇综述系统化了与氧化应激直接相关的乳腺癌代谢特征的信息。研究表明，这些氧化还原变化发生在各个层面，并影响人体内的许多调节系统。描述了乳腺癌中发生的生化过程的特征，从乍一看的非特异性和严格的生化到激素诱导的反应、遗传和表观遗传调节，这使得人们能够更广泛和更深入地了解肿瘤发生的原理，例如以及维持乳腺癌细胞的活力。人们已经研究了氧化应激激活的具体途径，作为对应激激素和雌激素过度产生的反应，并描述了减少其负面影响的具体方法。更充分地考虑了从不同侧面触发氧化还原反应的参与者的多样性：乳腺癌中的糖酵解活性，以及​​氨基酸和金属消耗的性质。详细讨论了金属在氧化应激中的作用。它们可以作为氧化应激的辅助因子和直接参与者，因为它们要么是脂质过氧化的触发机制，要么能够激活影响肿瘤发生的信号通路。人们特别关注乳腺肿瘤的遗传和表观遗传调控。解释了表观遗传调控的复杂级联机制，这使得重新考虑关于启动肿瘤过程的触发因素和途径、癌细胞的存活及其定位能力的现有观点成为可能。

This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring in breast cancer are described, ranging from nonspecific, at first glance, and strictly biochemical to hormone-induced reactions, genetic and epigenetic regulation, which allows for a broader and deeper understanding of the principles of oncogenesis, as well as maintaining the viability of cancer cells in the mammary gland. Specific pathways of the activation of oxidative stress have been studied as a response to the overproduction of stress hormones and estrogens, and specific ways to reduce its negative impact have been described. The diversity of participants that trigger redox reactions from different sides is considered more fully: glycolytic activity in breast cancer, and the nature of consumption of amino acids and metals. The role of metals in oxidative stress is discussed in detail. They can act as both co-factors and direct participants in oxidative stress, since they are either a trigger mechanism for lipid peroxidation or capable of activating signaling pathways that affect tumorigenesis. Special attention has been paid to the genetic and epigenetic regulation of breast tumors. A complex cascade of mechanisms of epigenetic regulation is explained, which made it possible to reconsider the existing opinion about the triggers and pathways for launching the oncological process, the survival of cancer cells and their ability to localize.