牛皮癣是一种终生、全身性、免疫介导的炎症性皮肤病，影响着世界上 1-3% 的人口，对生活质量的影响类似于癌症或糖尿病等疾病。遗传学是银屑病的最大单一危险因素，全基因组关联 (GWAS) 研究表明许多银屑病风险基因位于 IL-23/Th17 轴上。通过 GWAS 确定的潜在银屑病风险基因可以使用功能基因组学进行注释和表征，从而可以识别新的药物靶点并重新利用现有药物。本综述重点关注 IL-23/Th17 轴，深入了解相关的关键细胞类型、细胞因子和细胞内信号通路。这包括检查当前可用的生物治疗、停药后复发的时间以及主要/次要药物失败率，表明需要更好地了解银屑病的潜在遗传机制及其如何影响治疗。这可以允许患者针对最有可能在尽可能长的时间内减轻疾病负担的治疗进行分层。

Psoriasis is a lifelong, systemic, immune mediated inflammatory skin condition, affecting 1-3% of the world's population, with an impact on quality of life similar to diseases like cancer or diabetes. Genetics are the single largest risk factor in psoriasis, with Genome-Wide Association (GWAS) studies showing that many psoriasis risk genes lie along the IL-23/Th17 axis. Potential psoriasis risk genes determined through GWAS can be annotated and characterised using functional genomics, allowing the identification of novel drug targets and the repurposing of existing drugs. This review is focused on the IL-23/Th17 axis, providing an insight into key cell types, cytokines, and intracellular signaling pathways involved. This includes examination of currently available biological treatments, time to relapse post drug withdrawal, and rates of primary/secondary drug failure, showing the need for greater understanding of the underlying genetic mechanisms of psoriasis and how they can impact treatment. This could allow for patient stratification towards the treatment most likely to reduce the burden of disease for the longest period possible.