由耐碳青霉烯类革兰氏阴性菌和耐万古霉素革兰氏阳性菌引起的脑室炎和院内脑膜炎是日益严峻的治疗挑战。本文描述了一例由耐碳青霉烯类、产 KPC 的肺炎克雷伯菌和耐万古霉素屎肠球菌引起的脑室炎和菌血症，患者患有急性白血病，经美罗培南/伐波巴坦 (MVB)、利福平和利奈唑胺成功治疗。纸。本病例报告强调了多学科策略（包括感染病灶控制）对于治疗由多重耐药细菌引起的设备相关中枢神经系统 (CNS) 感染的重要性。考虑到新的耐药模式，需要对药物渗透到中枢神经系统以及联合治疗的必要性进行更多研究。

Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed.