生物医学不断发展，以确保对医疗保健产生重大和积极的影响，从而产生了水凝胶等创新和独特的必需品。基于壳聚糖的制剂因其在药物封装、运输和控释方面的多功能用途而脱颖而出，并辅以其生物相容性、生物降解性和非免疫原性。刺激响应水凝胶，也称为智能水凝胶，由于它们根据各种外部刺激做出响应和适应，因此具有严格调节的释放模式。此外，它们可以模仿内在组织的机械、生物和物理化学特性。这些特性使得刺激响应水凝胶能够提供尖端、有效和安全的治疗。该领域的不断进步需要对刺激响应性壳聚糖基水凝胶的生物医学应用的当前趋势和突破进行最新总结，这也是本次综述的目的。概括了对离子、pH、氧化还原电位、光、电场、温度和磁场敏感的水凝胶的一般数据。此外，还提到了对多种刺激有反应的制剂。重点关注基于壳聚糖的智能水凝胶，详细描述了其多方面的利用。广泛的应用范围包括神经系统疾病、肿瘤、伤口愈合和皮肤感染。关于智能壳聚糖水凝胶的现有数据强烈支持这样的观点：当前的方法和开发新颖的解决方案值得改进。本文为当前不断发展的领域的研究人员和实践者提供了宝贵的资源。

Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues' mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.