两种新的细胞松弛素衍生物，peniotrinins A (1) 和 B (2)，三种新的柑橘素衍生物，peniotrinins C-E (4, 5, 7)，和一种新的特特拉姆酸衍生物，peniotrinin F (12)，以及九种结构相关的已知衍生物化合物，是从 Peniophora sp. 的固体培养物中分离出来的。 SCSIO41203。基于光谱分析、量子化学计算和计算的 ECD，充分阐明了它们的结构，包括立体碳的绝对构型。有趣的是，1 是罕见的 6/5/5/5/6/13 六环细胞松弛素的第一个例子。我们筛选了上述化合物的抗前列腺癌活性，发现化合物3具有显着的抗前列腺癌细胞增殖作用，而化合物1和2在10 μM时表现出较弱的活性。然后我们通过透射电子显微镜和细胞免疫染色证实化合物3通过诱导methuosis发挥其抗前列腺癌作用，这表明化合物3可能首先被报道为潜在的抗前列腺methuosis诱导剂。

Two new cytochalasin derivatives, peniotrinins A (1) and B (2), three new citrinin derivatives, peniotrinins C-E (4, 5, 7), and one new tetramic acid derivative, peniotrinin F (12), along with nine structurally related known compounds, were isolated from the solid culture of Peniophora sp. SCSIO41203. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis, quantum chemical calculations, and the calculated ECD. Interestingly, 1 is the first example of a rare 6/5/5/5/6/13 hexacyclic cytochalasin. We screened the above compounds for their anti-prostate cancer activity and found that compound 3 had a significant anti-prostate cancer cell proliferation effect, while compounds 1 and 2 showed weak activity at 10 μM. We then confirmed that compound 3 exerts its anti-prostate cancer effect by inducing methuosis through transmission electron microscopy and cellular immunostaining, which suggested that compound 3 might be first reported as a potential anti-prostate methuosis inducer.