病毒感染引起宿主细胞代谢紊乱，而细胞代谢紊乱是肿瘤发生的主要原因之一，提示抗病毒分子可能通过调节细胞代谢而具有抗肿瘤活性。作为基因表达的关键调节因子，长链非编码RNA（lncRNA）在细胞代谢的调节中发挥着至关重要的作用。然而，抗病毒lncRNA对肿瘤发生的影响尚未被探索。为了解决这个问题，本研究对虾 lncRNA 的抗病毒和抗肿瘤能力进行了表征。结果表明，虾中具有抗病毒活性的lncRNA06可以跨物种地通过触发GCSCs凋亡来抑制GCSCs的肿瘤发生。虾 lncRNA06 可以吸收人 miR-17-5p，通过 miR-17-5p-p21 轴抑制 GCSC 的干性。同时，虾lncRNA06可以与ATP合酶亚基β（ATP5F1B）结合，增强GCSCs中ATP5F1B蛋白的稳定性，从而抑制GCSCs的肿瘤发生。体内数据表明，虾lncRNA06通过与ATP5F1B和miR-17-5p相互作用促进细胞凋亡并抑制GCSCs的干细胞性，从而抑制GCSCs的肿瘤发生。因此，我们的研究结果强调，抗病毒lncRNA具有抗肿瘤能力，抗病毒lncRNA可能成为治疗人类癌症的抗肿瘤库。

Virus infection causes the metabolic disorder of host cells, whereas the metabolic disorder of cells is one of the major causes of tumorigenesis, suggesting that antiviral molecules might possess anti-tumor activities by regulating cell metabolism. As the key regulators of gene expression, long non-coding RNAs (lncRNAs) play vital roles in the regulation of cell metabolism. However, the influence of antiviral lncRNAs on tumorigenesis has not been explored. To address this issue, the antiviral and anti-tumor capacities of shrimp lncRNAs were characterized in this study. The results revealed that shrimp lncRNA06, having antiviral activity in shrimp, could suppress the tumorigenesis of human gastric cancer stem cells (GCSCs) via triggering apoptosis of GCSCs in a cross-species manner. Shrimp lncRNA06 could sponge human miR-17-5p to suppress the stemness of GCSCs via the miR-17-5p-p21 axis. At the same time, shrimp lncRNA06 could bind to ATP synthase subunit beta (ATP5F1B) to enhance the stability of the ATP5F1B protein in GCSCs, thus suppressing the tumorigenesis of GCSCs. The in vivo data demonstrated that shrimp lncRNA06 promoted apoptosis and inhibited the stemness of GCSCs through interactions with ATP5F1B and miR-17-5p, leading to the suppression of the tumorigenesis of GCSCs. Therefore, our findings highlighted that antiviral lncRNAs possessed anti-tumor capacities and that antiviral lncRNAs could be the anti-tumor reservoir for the treatment of human cancers.