Denigrins H-L:来自新西兰 Dictyodendrilla c.f. 的 Denigrins D 和 E 的硫酸化衍生物dendyi 海洋海绵。
Denigrins H-L: Sulfated Derivatives of Denigrins D and E from a New Zealand Dictyodendrilla c.f. dendyi Marine Sponge.
发表日期:2024 May 20
作者:
Lauren Gris, Michèle R Prinsep, Linda M Peters, Christopher N Battershill
来源:
Marine Drugs
摘要:
从新西兰 Dictyodendrilla c.f. 的提取物中分离出五种新的硫酸化芳基吡咯和芳基吡咯酮生物碱、denigrins H-L (1-5) 以及两种已知化合物,即 dictyodendrin B 和 denigrin G。 dendy 海洋海绵。脱黑蛋白 H-L 代表硫酸化脱黑蛋白的第一个实例,其中脱黑蛋白 H 和 I (1-2) 作为脱黑蛋白 D 的衍生物,含有吡咯酮核心,脱黑蛋白 J-L (3-5) 作为脱黑蛋白 E (6) 的衍生物,含有吡咯核。通过解释 1D 和 2D NMR 光谱数据、ESI 和 HR-ESI-MS 光谱数据以及与文献数据的比较,阐明了它们的结构。化合物 1-5 以及之前从同一提取物中分离出的六种已知化合物,对 HeLa 宫颈癌细胞系表现出最小的细胞毒性。
Five new sulfated arylpyrrole and arylpyrrolone alkaloids, denigrins H-L (1-5), along with two known compounds, dictyodendrin B and denigrin G, were isolated from an extract of a New Zealand Dictyodendrilla c.f. dendyi marine sponge. Denigrins H-L represent the first examples of sulfated denigrins, with denigrins H and I (1-2), as derivatives of denigrin D, containing a pyrrolone core, and denigrins J-L (3-5), as derivatives of denigrin E (6), containing a pyrrole core. Their structures were elucidated by interpretation of 1D and 2D NMR spectroscopic data, ESI, and HR-ESI-MS spectrometric data, as well as comparison with literature data. Compounds 1-5, along with six known compounds previously isolated from the same extract, showed minimal cytotoxicity against the HeLa cervical cancer cell line.