长期肌肉骨骼并发症给儿童急性淋巴细胞白血病（cALL）幸存者带来了越来越大的负担。本研究旨在描述 PETALE 队列中 cALL 幸存者高风险亚组的身体损伤、活动限制和参与限制。这项横断面研究使用 PETALE 队列的观察数据，包括表现出高风险的幸存者亚组。 - 迟发效应的风险标准。结果测量包括髋部磁共振成像、最大等长肌力 (MIMS) 或扭矩 (MIMT)、运动范围 (ROM)、近串联平衡 (NTB)、6 分钟步行测试 (6MWT)、五次静坐-站立测试（FTSST）以及与健康相关的生活质量。进行了描述性统计和回归分析。幸存者（n = 97，24.2 ± 6.7岁）与参考值相比，握力、FTSST和NTB表现有限（p < 0.001）。 13 名参与者（14.6%，18 髋）患有髋骨坏死 (ON)（53.8% 为男性）。女性幸存者中髋部骨关节炎的严重程度较高（66.7% vs. 22.2%）。与没有髋关节ON的幸存者相比，髋关节外旋ROM的幸存者减少了髋关节外旋ROM（p<<0.05）。发现 MIMS 和 ROM 结果之间存在关系（r = 0.32，p < 0.01）以及与 6MWT 之间的关系（r = 0.39-0.41，p < 0.001）。我们的多元线性回归模型解释了 6MWT 方差的 27.6%。我们亚组中的幸存者具有临床上显着的身体损伤和活动限制，而髋关节 ON 的患者表现出最严重的髋关节损伤结果。这些发现强调了长期随访的重要性包括物理治疗评估，以帮助及早识别和管理 cALL 幸存者的身体损伤和活动限制。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下子公司）的独家许可。

Long-term musculoskeletal complications represent a growing burden for survivors of childhood acute lymphoblastic leukemia (cALL). This study aimed to describe physical impairments, activity limitations, and participation restrictions in a high-risk subgroup of cALL survivors of the PETALE cohort.This cross-sectional study, using observational data from the PETALE cohort, included a subgroup of survivors who presented high-risk criteria for late effects. Outcomes measures consisted of hip magnetic resonance imaging, maximal isometric muscle strength (MIMS) or torque (MIMT), range of motion (ROM), Near Tandem Balance (NTB), 6-Minute Walk Test (6MWT), Five Time Sit-to-Stand Test (FTSST), and health-related quality of life. Descriptive statistics and regression analyses were performed.Survivors (n = 97, 24.2 ± 6.7 years old) showed limited grip strength, FTSST, and NTB performance compared to reference values (p < 0.001). Thirteen participants (14.6%, 18 hips) had hip osteonecrosis (ON) (53.8% male). Higher severity hip ON was found in female survivors (66.7% vs. 22.2%). Survivors with hip ON had reduced hip external rotation ROM compared to those without (p < 0.05). Relationships were found between MIMS and ROM outcomes (r = 0.32, p < 0.01) and with 6MWT (r = 0.39-0.41, p < 0.001). Our multiple linear regression model explained 27.6% of the variance of the 6MWT.Survivors in our subgroup had clinically significant physical impairments and activity limitations, and those with hip ON showed worst hip impairment outcomes.These findings emphasize the importance of long-term follow-up including physical therapy assessment to help early identification and management of physical impairments and activity limitations in survivors of cALL.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.