乳腺癌发病率不断上升，是全球女性健康的主要威胁之一。最近，钯配合物已成为具有有效生物相容性和抗癌活性的令人印象深刻的候选者。因此，在本研究中，我们报告了一系列新的带有 NNS 钳配体的钯配合物，用于细胞毒性研究。苯硫酚/4-氯苯硫酚/4-甲基苯硫酚/4-甲氧基苯硫酚与2-溴-N-喹啉-8-基-乙酰胺在氢氧化钠存在下在乙醇中于80℃反应得到[C9H6N-NH-C( O)-CH2-S-Ar] [Ar = C6H5 (L1)、C6H4Cl-4 (L2)、C6H4Me-4 (L3) 和 C6H4-OMe-4 (L4)]。 L1-L4 与 Na2PdCl4 在甲醇中于室温下相应反应 3 小时，得到配合物 [(L1-H)PdCl] (C1)、[(L2-H)PdCl] (C2)、[(L3-H) PdCl] (C3) 和 [(L4-H)PdCl] (C4)。所有新化合物均已通过光谱分析进行表征。配合物 C1、C3 和 C4 的结构也已根据单晶 X 射线衍射数据确定。已研究了 L1-L4 和 C1-C4 对乳腺癌 4T1 和胰腺癌 MIA-PaCa-2 细胞的细胞毒性。观察到复合物 C2 和 C3 的 IC50 值与顺铂相当或更高。通过细胞形态分析和细胞骨架损伤评估，成功观察到癌细胞的应激形态和细胞死亡。

The continuously increasing rate of breast cancer is one of the major threats to female health worldwide. Recently, palladium complexes have emerged as impressive candidates with effective biocompatibility and anticancer activities. Hence, in the present study, we report a new series of palladium complexes bearing NNS pincer ligands for cytotoxicity studies. The reaction of thiophenol/4-chlorothiophenol/4-methylthiophenol/4-methoxythiophenol with 2-bromo-N-quinolin-8-yl-acetamide in the presence of sodium hydroxide in ethanol at 80 °C gave [C9H6N-NH-C(O)-CH2-S-Ar] [Ar = C6H5 (L1), C6H4Cl-4 (L2), C6H4Me-4 (L3), and C6H4-OMe-4 (L4)]. The corresponding reaction of L1-L4 with Na2PdCl4 in methanol at room temperature for 3 h resulted in complexes [(L1-H)PdCl] (C1), [(L2-H)PdCl] (C2), [(L3-H)PdCl] (C3), and [(L4-H)PdCl] (C4). All new compounds have been characterized by spectroscopic analyses. The structures of complexes C1, C3, and C4 have also been determined from single-crystal X-ray diffraction data. The cytotoxicities of L1-L4 and C1-C4 have been investigated for breast cancer 4T1 and pancreatic cancer MIA-PaCa-2 cells. The IC50 values for complexes C2 and C3 were observed to be comparable to or higher than those of cisplatin. The stressed morphology and cell death of cancerous cells were successfully observed through cellular morphology analysis and the assessment of cytoskeleton damage.