人乳头瘤病毒 (HPV) 已成为鼻腔鳞状细胞癌 (SNSCC) 的潜在病因，但对 HPV 患病率及其在 SNSCC 中的时间模式的清晰了解仍然难以捉摸。本研究旨在调查 HPV 检测和阳性率的时间趋势，并探讨与这些趋势相关的人口和地理因素。一项回顾性队列研究纳入了美国国家癌症数据库 (NCDB) 2011 年至 2017 年间诊断为侵袭性 SNSCC 的患者。使用相应的 95% 置信区间 (95% CI) 估算 HPV 阳性率 (PR) 和检测率。总体 HPV 检测率为 45.4% (N = 1762/3880)，HPV 检测率显着下降研究期间（调整后的 PR：0.97，95% CI：0.95 - 0.99，p < 0.001）。总体 HPV 阳性频率为 37.3% (N = 650/1741)，研究期间 HPV 阳性肿瘤的总体患病率显着增加（调整后 PR：1.04，95% CI：1.02 - 1.05，p < 0.001）。仅在白人群体中观察到 HPV 阳性率增加（未调整 PR：1.10，95% CI：1.06 - 1.14；p < 0.001）。 HPV 检测（范围：28.6% - 61.7%）和阳性率（范围：28.3% - 44.7%）均观察到显着的地理差异。这项研究为与 HPV 检测和阳性率相关的时间趋势和人口因素提供了新的见解。 SNSCC。尽管 HPV 阳性率不断上升，但检测率的差异仍然存在，凸显了标准化检测方案和有针对性的干预措施的必要性。版权所有 © 2024。由 Elsevier Ltd 出版。

Human papillomavirus (HPV) has emerged as a potential etiological factor in sinonasal squamous cell carcinoma (SNSCC), but a clear understanding of HPV prevalence and its temporal patterns in SNSCC remains elusive. This study aimed to investigate temporal trends in HPV testing and positivity rates, and explore demographic and geographic factors associated with these trends.A retrospective cohort study included patients diagnosed with invasive SNSCC between 2011 and 2017 from the US National Cancer Database (NCDB). Prevalence ratios (PR) of HPV positivity and testing rates were estimated with the corresponding 95% confidence interval (95% CI).The overall HPV testing rate was 45.4 % (N = 1762/3880), and the prevalence of HPV testing significantly decreased during the study period (adjusted PR: 0.97, 95 % CI: 0.95 - 0.99, p < 0.001). Overall HPV positivity frequency was 37.3 % (N = 650/1741), and the overall prevalence of HPV positive tumors significantly increased during the study period (adjusted PR: 1.04, 95 % CI: 1.02 - 1.05, p < 0.001). The increase in HPV positivity rate was observed solely in the white population (unadjusted PR: 1.10, 95 % CI: 1.06 - 1.14; p < 0.001). A significant geographical variation was observed for both HPV testing (range: 28.6 % - 61.7 %) and positivity (range: 28.3 % - 44.7 %).This study provides novel insights into the temporal trends and demographic factors associated with HPV testing and positivity in SNSCC. Despite increasing HPV positivity rates, disparities in testing rates persist, highlighting the need for standardized testing protocols and targeted interventions.Copyright © 2024. Published by Elsevier Ltd.