食用药材1（EMHs）是指一类具有食品和药品双重属性的物质。这些物质传统上用作食品，也被列入许多国际药典，包括欧洲药典、美国药典和中国药典。中医药中广泛使用的一些经典方剂包括一系列EMH，已被证明有效，具有明显的特点和优势。值得注意的是，这些EMHs和中国经典方剂2（CCPs）也因其低毒高效以及丰富的长期临床使用经验而引起了国际草药研究的关注。我们的目的是探索具有免疫炎症调节作用的 EMH 对现代癌症药物研究的潜在治疗作用。在本研究中，我们详细介绍了 CCP 中使用的一些 EMH，这些 EMH 在探索具有免疫炎症调节作用的现代药物的研究中显示出了巨大的研究潜力.以天然产物、食药材、中药、经方、免疫炎症、肿瘤微环境及一些相关同义词等关键词，从PubMed、Web of Science和ScienceDirect收集了近30年来约500篇出版物。重点讨论了活性成分而不是草药提取物或植物混合物，并对过去十年进行的研究进行了重点讨论和全面分析。讨论了 CCP 中使用的十多种源自 EMH 的天然产物及其免疫炎症调节活性，包括总结了增强抗肿瘤免疫力、调节炎症信号通路、降低免疫抑制细胞比例、抑制促炎细胞因子、免疫抑制因子和炎症介质的分泌。我们的研究结果证明了 CCP 中使用的 EMH 的免疫炎症调节作用，并提供了临床环境中癌症治疗的新思路。版权所有 © 2024 Elsevier GmbH。版权所有。

Edible and medicinal herbs1 (EMHs) refer to a class of substances with dual attribution of food and medicine. These substances are traditionally used as food and also listed in many international pharmacopoeias, including the European Pharmacopoeia, the United States Pharmacopoeia, and the Chinese Pharmacopoeia. Some classical formulas that are widely used in traditional Chinese medicine include a series of EMHs, which have been shown to be effective with obvious characteristics and advantages. Notably, these EMHs and Chinese classical prescriptions2 (CCPs) have also attracted attention in international herbal medicine research because of their low toxicity and high efficiency as well as the rich body of experience for their long-term clinical use.Our purpose is to explore the potential therapeutic effect of EMHs with immune-inflammatory modulation for the study of modern cancer drugs.In the present study, we present a detailed account of some EMHs used in CCPs that have shown considerable research potential in studies exploring modern drugs with immune-inflammatory modulation.Approximately 500 publications in the past 30 years were collected from PubMed, Web of Science and ScienceDirect using the keywords, such as natural products, edible and medicinal herbs, Chinese medicine, classical prescription, immune-inflammatory, tumor microenvironment and some related synonyms. The active ingredients instead of herbal extracts or botanical mixtures were focused on and the research conducted over the past decade were discussed emphatically and analyzed comprehensively.More than ten natural products derived from EMHs used in CCPs are discussed and their immune-inflammatory modulation activities, including enhancing antitumor immunity, regulating inflammatory signaling pathways, lowering the proportion of immunosuppressive cells, inhibiting the secretion of proinflammatory cytokines, immunosuppressive factors, and inflammatory mediators, are summarized.Our findings demonstrate the immune-inflammatory modulating role of those EMHs used in CCPs and provide new ideas for cancer treatment in clinical settings.Copyright © 2024 Elsevier GmbH. All rights reserved.