五味子（SC），木兰科植物，俗称“北五味子”，自古以来就以其极高的药用价值被《神农本草经》列为上品中药。北五味子多糖（SCPs）是SC中的活性成分，具有多种生物活性，包括免疫调节、抗肿瘤、抗氧化、保肝、抗炎和降血糖活性。研究表明，SCPs的提取方法有热水提取、水提醇沉、超声波辅助、微波辅助等。不同的提取方法会影响多糖的得率和纯度，为了提高SCPs的提取得率，可以组合两种或多种提取方法。 SCP主要由葡萄糖、甘露糖、鼠李糖、半乳糖、半乳糖醛酸和阿拉伯糖组成。本文旨在系统综述近年来国内外在SCPs的提取分离方法、结构表征、生物活性等方面的研究进展。这深入探讨了SCP的药理活性和作用机制，为SC的研究和临床应用提供了一定的参考。Copyright © 2024. Published by Elsevier B.V.

Schisandra chinensis (SC), a plant of the Magnoliaceae family, commonly known as "North Schisandra chinensis", has been listed as a top-grade Chinese medicine in the Shennong Materia Medica Classic for its high medicinal value since ancient times. Polysaccharides from S. chinensis fruits (SCPs) are an active component in SC, which have various biological activity, including immune regulation, anti-tumor, antioxidant, liver protective, anti-inflammatory and hypoglycemic activity. Research has shown that the extraction methods of SCPs include hot water extraction, water extraction and alcohol precipitation, ultrasonic-assisted, microwave-assisted and so on. Different extraction methods can affect the yield and purity of polysaccharides, and to improve the extraction yield of SCPs, two or more extraction methods can be combined. SCPs are mainly composed of glucose, mannose, rhamnose, galactose, galacturonic acid and arabinose. This article aims to provide a systematic review of the research progress in the extraction and separation methods, structural characterization, and biological activity of SCPs both domestically and internationally in recent years. This deeply explores the pharmacological activity and action mechanism of SCPs, and provides a certain point of reference for the research and clinical application of SC.Copyright © 2024. Published by Elsevier B.V.