意义未明的 T 区样细胞 (TZUS) 与 T 区淋巴瘤细胞具有相同的表型模式 (CD45-CD5)，几年前首次在健康老年美国金毛猎犬的外周血 (PB) 中被描述。 GR）。膀胱和眼部疾病史增加了美国 GR 人群中循环 TZUS 的几率。由于不同来源的犬只之间可能存在差异，因此我们筛选了 489 份 PB 样本，以评估生活在意大利的犬只中存在循环 TZUS 的潜在因素。总体而言，在 174 个 (35.6%) 样本中发现了 TZUS。在 83 个临床变量中，与性别、年龄、肿瘤诊断、肿瘤病史、传染病或寄生虫病史、骨关节病史、是否存在创伤性病变或异物以及淋巴细胞计数存在显着相关性。在多变量分析中，只有年龄和肿瘤病史保留显着性（分别为 p=0.019 和 p=0.036）。因此，年龄较大和肿瘤病史是意大利犬循环 TZUS 的主要因素。未来的研究应侧重于阐明 TZUS 的生物学作用并确定其识别的可重复标准，将其与渗透 TZL 区分开来。版权所有 © 2024。由 Elsevier Ltd 出版。

T-zone-like cells of undetermined significance (TZUS) share the same phenotypic pattern (CD45-CD5+) with T-zone lymphoma cells and were first described a few years ago in the peripheral blood (PB) of healthy aged American Golden retrievers (GR). History of bladder and eye disease increased the odd of circulating TZUS in the American GR population. Since differences among dogs may exist according to the geographical region of origin, herein we screened 489 PB samples to assess potential factors predisposing to the presence of circulating TZUS in dogs living in Italy. Overall, TZUS were found in 174 (35.6%) samples. Among 83 clinical variables, significant associations emerged with sex, age, diagnosis of neoplasia, history of neoplasia, history of infectious or parasitic disease, history of osteoarticular disease, presence of traumatic lesions or foreign bodies, and lymphocytes count. Only age and history of neoplasia retained significance at multivariate analysis (p=0.019 and p=0.036, respectively). Thus, older age and history of neoplasia are the main factors associated with circulating TZUS in Italian dogs. Future studies should focus on elucidating the biological role of TZUS and determining reproducible criteria for their identification, distinguishing them from infiltrating TZL.Copyright © 2024. Published by Elsevier Ltd.